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Analysis and Practical Guideline of Constraint-Based Boolean Method in Genetic Network Inference

Boolean-based method, despite of its simplicity, would be a more attractive approach for inferring a network from high-throughput expression data if its effectiveness has not been limited by high false positive prediction. In this study, we explored factors that could simply be adjusted to improve t...

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Detalles Bibliográficos
Autores principales: Saithong, Treenut, Bumee, Somkid, Liamwirat, Chalothorn, Meechai, Asawin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3260258/
https://www.ncbi.nlm.nih.gov/pubmed/22272315
http://dx.doi.org/10.1371/journal.pone.0030232
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author Saithong, Treenut
Bumee, Somkid
Liamwirat, Chalothorn
Meechai, Asawin
author_facet Saithong, Treenut
Bumee, Somkid
Liamwirat, Chalothorn
Meechai, Asawin
author_sort Saithong, Treenut
collection PubMed
description Boolean-based method, despite of its simplicity, would be a more attractive approach for inferring a network from high-throughput expression data if its effectiveness has not been limited by high false positive prediction. In this study, we explored factors that could simply be adjusted to improve the accuracy of inferring networks. Our work focused on the analysis of the effects of discretisation methods, biological constraints, and stringency of Boolean function assignment on the performance of Boolean network, including accuracy, precision, specificity and sensitivity, using three sets of microarray time-series data. The study showed that biological constraints have pivotal influence on the network performance over the other factors. It can reduce the variation in network performance resulting from the arbitrary selection of discretisation methods and stringency settings. We also presented the master Boolean network as an approach to establish the unique solution for Boolean analysis. The information acquired from the analysis was summarised and deployed as a general guideline for an efficient use of Boolean-based method in the network inference. In the end, we provided an example of the use of such a guideline in the study of Arabidopsis circadian clock genetic network from which much interesting biological information can be inferred.
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spelling pubmed-32602582012-01-23 Analysis and Practical Guideline of Constraint-Based Boolean Method in Genetic Network Inference Saithong, Treenut Bumee, Somkid Liamwirat, Chalothorn Meechai, Asawin PLoS One Research Article Boolean-based method, despite of its simplicity, would be a more attractive approach for inferring a network from high-throughput expression data if its effectiveness has not been limited by high false positive prediction. In this study, we explored factors that could simply be adjusted to improve the accuracy of inferring networks. Our work focused on the analysis of the effects of discretisation methods, biological constraints, and stringency of Boolean function assignment on the performance of Boolean network, including accuracy, precision, specificity and sensitivity, using three sets of microarray time-series data. The study showed that biological constraints have pivotal influence on the network performance over the other factors. It can reduce the variation in network performance resulting from the arbitrary selection of discretisation methods and stringency settings. We also presented the master Boolean network as an approach to establish the unique solution for Boolean analysis. The information acquired from the analysis was summarised and deployed as a general guideline for an efficient use of Boolean-based method in the network inference. In the end, we provided an example of the use of such a guideline in the study of Arabidopsis circadian clock genetic network from which much interesting biological information can be inferred. Public Library of Science 2012-01-17 /pmc/articles/PMC3260258/ /pubmed/22272315 http://dx.doi.org/10.1371/journal.pone.0030232 Text en Saithong et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Saithong, Treenut
Bumee, Somkid
Liamwirat, Chalothorn
Meechai, Asawin
Analysis and Practical Guideline of Constraint-Based Boolean Method in Genetic Network Inference
title Analysis and Practical Guideline of Constraint-Based Boolean Method in Genetic Network Inference
title_full Analysis and Practical Guideline of Constraint-Based Boolean Method in Genetic Network Inference
title_fullStr Analysis and Practical Guideline of Constraint-Based Boolean Method in Genetic Network Inference
title_full_unstemmed Analysis and Practical Guideline of Constraint-Based Boolean Method in Genetic Network Inference
title_short Analysis and Practical Guideline of Constraint-Based Boolean Method in Genetic Network Inference
title_sort analysis and practical guideline of constraint-based boolean method in genetic network inference
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3260258/
https://www.ncbi.nlm.nih.gov/pubmed/22272315
http://dx.doi.org/10.1371/journal.pone.0030232
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