Opposite Effects of Mepyramine on JNJ 7777120-Induced Amelioration of Experimentally Induced Asthma in Mice in Sensitization and Provocation

BACKGROUND: Histamine is detected in high concentrations in the airways during an allergic asthma response. In a murine model of allergic asthma, JNJ 7777120, an antagonist at the histamine H(4) receptor, reduces asthmatic symptoms, while the histamine H(1) receptor-selective antagonist mepyramine i...

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Detalles Bibliográficos
Autores principales: Beermann, Silke, Glage, Silke, Jonigk, Danny, Seifert, Roland, Neumann, Detlef
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3260279/
https://www.ncbi.nlm.nih.gov/pubmed/22272324
http://dx.doi.org/10.1371/journal.pone.0030285

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3260279/
https://www.ncbi.nlm.nih.gov/pubmed/22272324
http://dx.doi.org/10.1371/journal.pone.0030285

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