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Opposite Effects of Mepyramine on JNJ 7777120-Induced Amelioration of Experimentally Induced Asthma in Mice in Sensitization and Provocation

BACKGROUND: Histamine is detected in high concentrations in the airways during an allergic asthma response. In a murine model of allergic asthma, JNJ 7777120, an antagonist at the histamine H(4) receptor, reduces asthmatic symptoms, while the histamine H(1) receptor-selective antagonist mepyramine i...

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Detalles Bibliográficos
Autores principales:	Beermann, Silke, Glage, Silke, Jonigk, Danny, Seifert, Roland, Neumann, Detlef
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3260279/ https://www.ncbi.nlm.nih.gov/pubmed/22272324 http://dx.doi.org/10.1371/journal.pone.0030285

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