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A Carotenoid Health Index Based on Plasma Carotenoids and Health Outcomes

While there have been many studies on health outcomes that have included measurements of plasma carotenoids, this data has not been reviewed and assembled into a useful form. In this review sixty-two studies of plasma carotenoids and health outcomes, mostly prospective cohort studies or population-b...

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Autor principal: Donaldson, Michael S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3260489/
https://www.ncbi.nlm.nih.gov/pubmed/22292108
http://dx.doi.org/10.3390/nu3121003
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author Donaldson, Michael S.
author_facet Donaldson, Michael S.
author_sort Donaldson, Michael S.
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description While there have been many studies on health outcomes that have included measurements of plasma carotenoids, this data has not been reviewed and assembled into a useful form. In this review sixty-two studies of plasma carotenoids and health outcomes, mostly prospective cohort studies or population-based case-control studies, are analyzed together to establish a carotenoid health index. Five cutoff points are established across the percentiles of carotenoid concentrations in populations, from the tenth to ninetieth percentile. The cutoff points (mean ± standard error of the mean) are 1.11 ± 0.08, 1.47 ± 0.08, 1.89 ± 0.08, 2.52 ± 0.13, and 3.07 ± 0.20 µM. For all cause mortality there seems to be a low threshold effect with protection above every cutoff point but the lowest. But for metabolic syndrome and cancer outcomes there tends to be significant positive health outcomes only above the higher cutoff points, perhaps as a triage effect. Based on this data a carotenoid health index is proposed with risk categories as follows: very high risk: <1 µM, high risk: 1-1.5 µM, moderate risk: 1.5-2.5 µM, low risk: 2.5-4 µM, and very low risk: >4 µM. Over 95 percent of the USA population falls into the moderate or high risk category of the carotenoid health index.
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spelling pubmed-32604892012-01-30 A Carotenoid Health Index Based on Plasma Carotenoids and Health Outcomes Donaldson, Michael S. Nutrients Review While there have been many studies on health outcomes that have included measurements of plasma carotenoids, this data has not been reviewed and assembled into a useful form. In this review sixty-two studies of plasma carotenoids and health outcomes, mostly prospective cohort studies or population-based case-control studies, are analyzed together to establish a carotenoid health index. Five cutoff points are established across the percentiles of carotenoid concentrations in populations, from the tenth to ninetieth percentile. The cutoff points (mean ± standard error of the mean) are 1.11 ± 0.08, 1.47 ± 0.08, 1.89 ± 0.08, 2.52 ± 0.13, and 3.07 ± 0.20 µM. For all cause mortality there seems to be a low threshold effect with protection above every cutoff point but the lowest. But for metabolic syndrome and cancer outcomes there tends to be significant positive health outcomes only above the higher cutoff points, perhaps as a triage effect. Based on this data a carotenoid health index is proposed with risk categories as follows: very high risk: <1 µM, high risk: 1-1.5 µM, moderate risk: 1.5-2.5 µM, low risk: 2.5-4 µM, and very low risk: >4 µM. Over 95 percent of the USA population falls into the moderate or high risk category of the carotenoid health index. MDPI 2011-12-08 /pmc/articles/PMC3260489/ /pubmed/22292108 http://dx.doi.org/10.3390/nu3121003 Text en © 2011 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Donaldson, Michael S.
A Carotenoid Health Index Based on Plasma Carotenoids and Health Outcomes
title A Carotenoid Health Index Based on Plasma Carotenoids and Health Outcomes
title_full A Carotenoid Health Index Based on Plasma Carotenoids and Health Outcomes
title_fullStr A Carotenoid Health Index Based on Plasma Carotenoids and Health Outcomes
title_full_unstemmed A Carotenoid Health Index Based on Plasma Carotenoids and Health Outcomes
title_short A Carotenoid Health Index Based on Plasma Carotenoids and Health Outcomes
title_sort carotenoid health index based on plasma carotenoids and health outcomes
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3260489/
https://www.ncbi.nlm.nih.gov/pubmed/22292108
http://dx.doi.org/10.3390/nu3121003
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