A CMOS Time-Resolved Fluorescence Lifetime Analysis Micro-System

We describe a CMOS-based micro-system for time-resolved fluorescence lifetime analysis. It comprises a 16 × 4 array of single-photon avalanche diodes (SPADs) fabricated in 0.35 μm high-voltage CMOS technology with in-pixel time-gated photon counting circuitry and a second device incorporating an 8 ×...

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Autores principales: Rae, Bruce R., Muir, Keith R., Gong, Zheng, McKendry, Jonathan, Girkin, John M., Gu, Erdan, Renshaw, David, Dawson, Martin D., Henderson, Robert K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2009
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3260641/
https://www.ncbi.nlm.nih.gov/pubmed/22291564
http://dx.doi.org/10.3390/s91109255
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author Rae, Bruce R.
Muir, Keith R.
Gong, Zheng
McKendry, Jonathan
Girkin, John M.
Gu, Erdan
Renshaw, David
Dawson, Martin D.
Henderson, Robert K.
author_facet Rae, Bruce R.
Muir, Keith R.
Gong, Zheng
McKendry, Jonathan
Girkin, John M.
Gu, Erdan
Renshaw, David
Dawson, Martin D.
Henderson, Robert K.
author_sort Rae, Bruce R.
collection PubMed
description We describe a CMOS-based micro-system for time-resolved fluorescence lifetime analysis. It comprises a 16 × 4 array of single-photon avalanche diodes (SPADs) fabricated in 0.35 μm high-voltage CMOS technology with in-pixel time-gated photon counting circuitry and a second device incorporating an 8 × 8 AlInGaN blue micro-pixellated light-emitting diode (micro-LED) array bump-bonded to an equivalent array of LED drivers realized in a standard low-voltage 0.35 μm CMOS technology, capable of producing excitation pulses with a width of 777 ps (FWHM). This system replaces instrumentation based on lasers, photomultiplier tubes, bulk optics and discrete electronics with a PC-based micro-system. Demonstrator lifetime measurements of colloidal quantum dot and Rhodamine samples are presented.
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spelling pubmed-32606412012-01-30 A CMOS Time-Resolved Fluorescence Lifetime Analysis Micro-System Rae, Bruce R. Muir, Keith R. Gong, Zheng McKendry, Jonathan Girkin, John M. Gu, Erdan Renshaw, David Dawson, Martin D. Henderson, Robert K. Sensors (Basel) Article We describe a CMOS-based micro-system for time-resolved fluorescence lifetime analysis. It comprises a 16 × 4 array of single-photon avalanche diodes (SPADs) fabricated in 0.35 μm high-voltage CMOS technology with in-pixel time-gated photon counting circuitry and a second device incorporating an 8 × 8 AlInGaN blue micro-pixellated light-emitting diode (micro-LED) array bump-bonded to an equivalent array of LED drivers realized in a standard low-voltage 0.35 μm CMOS technology, capable of producing excitation pulses with a width of 777 ps (FWHM). This system replaces instrumentation based on lasers, photomultiplier tubes, bulk optics and discrete electronics with a PC-based micro-system. Demonstrator lifetime measurements of colloidal quantum dot and Rhodamine samples are presented. Molecular Diversity Preservation International (MDPI) 2009-11-18 /pmc/articles/PMC3260641/ /pubmed/22291564 http://dx.doi.org/10.3390/s91109255 Text en © 2009 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Article
Rae, Bruce R.
Muir, Keith R.
Gong, Zheng
McKendry, Jonathan
Girkin, John M.
Gu, Erdan
Renshaw, David
Dawson, Martin D.
Henderson, Robert K.
A CMOS Time-Resolved Fluorescence Lifetime Analysis Micro-System
title A CMOS Time-Resolved Fluorescence Lifetime Analysis Micro-System
title_full A CMOS Time-Resolved Fluorescence Lifetime Analysis Micro-System
title_fullStr A CMOS Time-Resolved Fluorescence Lifetime Analysis Micro-System
title_full_unstemmed A CMOS Time-Resolved Fluorescence Lifetime Analysis Micro-System
title_short A CMOS Time-Resolved Fluorescence Lifetime Analysis Micro-System
title_sort cmos time-resolved fluorescence lifetime analysis micro-system
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3260641/
https://www.ncbi.nlm.nih.gov/pubmed/22291564
http://dx.doi.org/10.3390/s91109255
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