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Impact of ethnicity on gestational diabetes identified with the WHO and the modified International Association of Diabetes and Pregnancy Study Groups criteria: a population-based cohort study

OBJECTIVE: The International Association of Diabetes and Pregnancy Study Groups (IADPSG) recently proposed new criteria for diagnosing gestational diabetes mellitus (GDM). We compared prevalence rates, risk factors, and the effect of ethnicity using the World Health Organization (WHO) and modified I...

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Autores principales: Jenum, Anne K, Mørkrid, Kjersti, Sletner, Line, Vange, Siri, Torper, Johan L, Nakstad, Britt, Voldner, Nanna, Rognerud-Jensen, Odd H, Berntsen, Sveinung, Mosdøl, Annhild, Skrivarhaug, Torild, Vårdal, Mari H, Holme, Ingar, Yajnik, Chittaranjan S, Birkeland, Kåre I
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioScientifica 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3260695/
https://www.ncbi.nlm.nih.gov/pubmed/22108914
http://dx.doi.org/10.1530/EJE-11-0866
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author Jenum, Anne K
Mørkrid, Kjersti
Sletner, Line
Vange, Siri
Torper, Johan L
Nakstad, Britt
Voldner, Nanna
Rognerud-Jensen, Odd H
Berntsen, Sveinung
Mosdøl, Annhild
Skrivarhaug, Torild
Vårdal, Mari H
Holme, Ingar
Yajnik, Chittaranjan S
Birkeland, Kåre I
author_facet Jenum, Anne K
Mørkrid, Kjersti
Sletner, Line
Vange, Siri
Torper, Johan L
Nakstad, Britt
Voldner, Nanna
Rognerud-Jensen, Odd H
Berntsen, Sveinung
Mosdøl, Annhild
Skrivarhaug, Torild
Vårdal, Mari H
Holme, Ingar
Yajnik, Chittaranjan S
Birkeland, Kåre I
author_sort Jenum, Anne K
collection PubMed
description OBJECTIVE: The International Association of Diabetes and Pregnancy Study Groups (IADPSG) recently proposed new criteria for diagnosing gestational diabetes mellitus (GDM). We compared prevalence rates, risk factors, and the effect of ethnicity using the World Health Organization (WHO) and modified IADPSG criteria. METHODS: This was a population-based cohort study of 823 (74% of eligible) healthy pregnant women, of whom 59% were from ethnic minorities. Universal screening was performed at 28±2 weeks of gestation with the 75 g oral glucose tolerance test (OGTT). Venous plasma glucose (PG) was measured on site. GDM was diagnosed as per the definition of WHO criteria as fasting PG (FPG) ≥7.0 or 2-h PG ≥7.8 mmol/l; and as per the modified IADPSG criteria as FPG ≥5.1 or 2-h PG ≥8.5 mmol/l. RESULTS: OGTT was performed in 759 women. Crude GDM prevalence was 13.0% with WHO (Western Europeans 11%, ethnic minorities 15%, P=0.14) and 31.5% with modified IADPSG criteria (Western Europeans 24%, ethnic minorities 37%, P< 0.001). Using the WHO criteria, ethnic minority origin was an independent predictor (South Asians, odds ratio (OR) 2.24 (95% confidence interval (CI) 1.26–3.97); Middle Easterners, OR 2.13 (1.12–4.08)) after adjustments for age, parity, and prepregnant body mass index (BMI). This increased OR was unapparent after further adjustments for body height (proxy for early life socioeconomic status), education and family history of diabetes. Using the modified IADPSG criteria, prepregnant BMI (1.09 (1.05–1.13)) and ethnic minority origin (South Asians, 2.54 (1.56–4.13)) were independent predictors, while education, body height and family history had little impact. CONCLUSION: GDM prevalence was overall 2.4-times higher with the modified IADPSG criteria compared with the WHO criteria. The new criteria identified many subjects with a relatively mild increase in FPG, strongly associated with South Asian origin and prepregnant overweight.
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spelling pubmed-32606952012-02-01 Impact of ethnicity on gestational diabetes identified with the WHO and the modified International Association of Diabetes and Pregnancy Study Groups criteria: a population-based cohort study Jenum, Anne K Mørkrid, Kjersti Sletner, Line Vange, Siri Torper, Johan L Nakstad, Britt Voldner, Nanna Rognerud-Jensen, Odd H Berntsen, Sveinung Mosdøl, Annhild Skrivarhaug, Torild Vårdal, Mari H Holme, Ingar Yajnik, Chittaranjan S Birkeland, Kåre I Eur J Endocrinol Clinical Study OBJECTIVE: The International Association of Diabetes and Pregnancy Study Groups (IADPSG) recently proposed new criteria for diagnosing gestational diabetes mellitus (GDM). We compared prevalence rates, risk factors, and the effect of ethnicity using the World Health Organization (WHO) and modified IADPSG criteria. METHODS: This was a population-based cohort study of 823 (74% of eligible) healthy pregnant women, of whom 59% were from ethnic minorities. Universal screening was performed at 28±2 weeks of gestation with the 75 g oral glucose tolerance test (OGTT). Venous plasma glucose (PG) was measured on site. GDM was diagnosed as per the definition of WHO criteria as fasting PG (FPG) ≥7.0 or 2-h PG ≥7.8 mmol/l; and as per the modified IADPSG criteria as FPG ≥5.1 or 2-h PG ≥8.5 mmol/l. RESULTS: OGTT was performed in 759 women. Crude GDM prevalence was 13.0% with WHO (Western Europeans 11%, ethnic minorities 15%, P=0.14) and 31.5% with modified IADPSG criteria (Western Europeans 24%, ethnic minorities 37%, P< 0.001). Using the WHO criteria, ethnic minority origin was an independent predictor (South Asians, odds ratio (OR) 2.24 (95% confidence interval (CI) 1.26–3.97); Middle Easterners, OR 2.13 (1.12–4.08)) after adjustments for age, parity, and prepregnant body mass index (BMI). This increased OR was unapparent after further adjustments for body height (proxy for early life socioeconomic status), education and family history of diabetes. Using the modified IADPSG criteria, prepregnant BMI (1.09 (1.05–1.13)) and ethnic minority origin (South Asians, 2.54 (1.56–4.13)) were independent predictors, while education, body height and family history had little impact. CONCLUSION: GDM prevalence was overall 2.4-times higher with the modified IADPSG criteria compared with the WHO criteria. The new criteria identified many subjects with a relatively mild increase in FPG, strongly associated with South Asian origin and prepregnant overweight. BioScientifica 2012-02 /pmc/articles/PMC3260695/ /pubmed/22108914 http://dx.doi.org/10.1530/EJE-11-0866 Text en © 2012 European Society of Endocrinology http://www.bioscientifica.com/journals/reuselicenceeje/ This is an Open Access article distributed under the terms of the European Journal of Endocrinology's Re-use Licence (http://www.bioscientifica.com/journals/reuselicenceeje/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Jenum, Anne K
Mørkrid, Kjersti
Sletner, Line
Vange, Siri
Torper, Johan L
Nakstad, Britt
Voldner, Nanna
Rognerud-Jensen, Odd H
Berntsen, Sveinung
Mosdøl, Annhild
Skrivarhaug, Torild
Vårdal, Mari H
Holme, Ingar
Yajnik, Chittaranjan S
Birkeland, Kåre I
Impact of ethnicity on gestational diabetes identified with the WHO and the modified International Association of Diabetes and Pregnancy Study Groups criteria: a population-based cohort study
title Impact of ethnicity on gestational diabetes identified with the WHO and the modified International Association of Diabetes and Pregnancy Study Groups criteria: a population-based cohort study
title_full Impact of ethnicity on gestational diabetes identified with the WHO and the modified International Association of Diabetes and Pregnancy Study Groups criteria: a population-based cohort study
title_fullStr Impact of ethnicity on gestational diabetes identified with the WHO and the modified International Association of Diabetes and Pregnancy Study Groups criteria: a population-based cohort study
title_full_unstemmed Impact of ethnicity on gestational diabetes identified with the WHO and the modified International Association of Diabetes and Pregnancy Study Groups criteria: a population-based cohort study
title_short Impact of ethnicity on gestational diabetes identified with the WHO and the modified International Association of Diabetes and Pregnancy Study Groups criteria: a population-based cohort study
title_sort impact of ethnicity on gestational diabetes identified with the who and the modified international association of diabetes and pregnancy study groups criteria: a population-based cohort study
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3260695/
https://www.ncbi.nlm.nih.gov/pubmed/22108914
http://dx.doi.org/10.1530/EJE-11-0866
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