Cargando…

Monomeric α-Synuclein Binds Congo Red Micelles in a Disordered Manner

[Image: see text] The histological dye Congo Red (CR) previously has been shown to inhibit α-synuclein (aS) fibrillation, but the mode of this inhibition remained unclear. Because of favorable exchange kinetics, interaction between CR and aS lends itself to a detailed nuclear magnetic resonance stud...

Descripción completa

Detalles Bibliográficos
Autores principales:	Maltsev, Alexander S., Grishaev, Alexander, Bax, Ad
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2011
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3260784/ https://www.ncbi.nlm.nih.gov/pubmed/22242826 http://dx.doi.org/10.1021/bi201435d

Ejemplares similares

Impact of N-Terminal Acetylation of α-Synuclein on Its Random Coil and Lipid Binding Properties
por: Maltsev, Alexander S., et al.
Publicado: (2012)

Differential Phospholipid Binding of α-Synuclein Variants Implicated in Parkinson’s Disease Revealed by Solution NMR Spectroscopy
por: Bodner, Christina R., et al.
Publicado: (2009)

Identification of Synaptosomal Proteins Binding to Monomeric and Oligomeric α-Synuclein
por: Betzer, Cristine, et al.
Publicado: (2015)

Site-Specific Interaction between α-Synuclein and Membranes Probed by NMR-Observed Methionine Oxidation Rates
por: Maltsev, Alexander S., et al.
Publicado: (2013)

Improved Cross Validation of a Static Ubiquitin Structure Derived from High Precision Residual Dipolar Couplings Measured in a Drug-Based Liquid Crystalline Phase
por: Maltsev, Alexander S., et al.
Publicado: (2014)

DJ-1 Acts as a Scavenger of α-Synuclein Oligomers and Restores Monomeric Glycated α-Synuclein
por: Atieh, Tamr B., et al.
Publicado: (2021)

Conformational Equilibria in Monomeric α-Synuclein at the Single-Molecule Level
por: Sandal, Massimo, et al.
Publicado: (2008)

Monomeric α‐synuclein activates the plasma membrane calcium pump
por: Kowalski, Antoni, et al.
Publicado: (2023)

Imino Hydrogen Positions in Nucleic Acids from Density Functional Theory Validated by NMR Residual Dipolar Couplings
por: Grishaev, Alexander, et al.
Publicado: (2012)

Understanding the dynamics of monomeric, dimeric, and tetrameric α‐synuclein structures in water
por: Mane, Jonathan Y., et al.
Publicado: (2016)

A Relationship between the Transient Structure in the Monomeric State and the Aggregation Propensities of α-Synuclein and β-Synuclein
por: Allison, Jane R., et al.
Publicado: (2014)

Side Chain Conformational Distributions of a Small Protein Derived from Model-Free Analysis of a Large Set of Residual Dipolar Couplings
por: Li, Fang, et al.
Publicado: (2015)

Different Structural Conformers of Monomeric α-Synuclein Identified after Lyophilizing and Freezing
por: Stephens, Amberley D., et al.
Publicado: (2018)

The Impact of Hydrogen Bonding on Amide (1)H Chemical Shift Anisotropy Studied by Cross-Correlated Relaxation and Liquid Crystal NMR Spectroscopy
por: Yao, Lishan, et al.
Publicado: (2010)

Improved Fitting of Solution X-ray Scattering Data to Macromolecular Structures and Structural Ensembles by Explicit Water Modeling
por: Grishaev, Alexander, et al.
Publicado: (2010)

Oleuropein aglycone stabilizes the monomeric α-synuclein and favours the growth of non-toxic aggregates
por: Palazzi, Luana, et al.
Publicado: (2018)

Inflammatory Responses to Monomeric and Aggregated α-Synuclein in Peripheral Blood of Parkinson Disease Patients
por: Piancone, Federica, et al.
Publicado: (2021)

Single-vesicle imaging reveals lipid-selective and stepwise membrane disruption by monomeric α-synuclein
por: Hannestad, Jonas K., et al.
Publicado: (2020)

Salient Features of Monomeric Alpha-Synuclein Revealed by NMR Spectroscopy
por: Kim, Do-Hyoung, et al.
Publicado: (2020)

Excess membrane binding of monomeric alpha-, beta- and gamma-synuclein is invariably associated with inclusion formation and toxicity
por: Kim, Tae-Eun, et al.
Publicado: (2021)

Tyrosine Nitroxidation Does Not Affect the Ability of α-Synuclein to Bind Anionic Micelles, but It Diminishes Its Ability to Bind and Assemble Synaptic-like Vesicles
por: Uceda, Ana Belén, et al.
Publicado: (2023)

The influence of N-terminal acetylation on micelle-induced conformational changes and aggregation of α-Synuclein
por: Ruzafa, David, et al.
Publicado: (2017)

Nuclear Magnetic Resonance Observation of α-Synuclein Membrane Interaction by Monitoring the Acetylation Reactivity of Its Lysine Side Chains
por: Lee, Jung Ho, et al.
Publicado: (2016)

p21-activated kinase 4 controls the aggregation of α-synuclein by reducing the monomeric and aggregated forms of α-synuclein: involvement of the E3 ubiquitin ligase NEDD4-1
por: Won, So-Yoon, et al.
Publicado: (2022)

Expression of α-synuclein is regulated in a neuronal cell type-dependent manner
por: Taguchi, Katsutoshi, et al.
Publicado: (2018)

Small Molecules Detected by Second-Harmonic Generation Modulate the Conformation of Monomeric α-Synuclein and Reduce Its Aggregation in Cells
por: Moree, Ben, et al.
Publicado: (2015)

Congo Red and amyloids: history and relationship
por: Yakupova, Elmira I., et al.
Publicado: (2019)

Synaptic vesicle binding of α-synuclein is modulated by β- and γ-synucleins
por: Carnazza, Kathryn E., et al.
Publicado: (2022)

Nanobodies raised against monomeric ɑ-synuclein inhibit fibril formation and destabilize toxic oligomeric species
por: Iljina, Marija, et al.
Publicado: (2017)

Insulin-degrading enzyme prevents α-synuclein fibril formation in a nonproteolytical manner
por: Sharma, Sandeep K., et al.
Publicado: (2015)

Extent of N-terminus exposure of monomeric alpha-synuclein determines its aggregation propensity
por: Stephens, Amberley D., et al.
Publicado: (2020)

Polyphosphates induce amyloid fibril formation of α-synuclein in concentration-dependent distinct manners
por: Yamaguchi, Keiichi, et al.
Publicado: (2021)

Cooperativity of α-Synuclein Binding to Lipid Membranes
por: Makasewicz, Katarzyna, et al.
Publicado: (2021)

Binding Stability of Antibody—α-Synuclein Complexes Predicts the Protective Efficacy of Anti-α-synuclein Antibodies
por: Höllerhage, Matthias, et al.
Publicado: (2022)

β-Synuclein suppresses both the initiation and amplification steps of α-synuclein aggregation via competitive binding to surfaces
por: Brown, James W. P., et al.
Publicado: (2016)

α-Synuclein-derived lipoparticles in the study of α-Synuclein amyloid fibril formation
por: Falke, Marcel, et al.
Publicado: (2019)

Adenosine A1 receptor ligands bind to α-synuclein: implications for α-synuclein misfolding and α-synucleinopathy in Parkinson’s disease
por: Jakova, Elisabet, et al.
Publicado: (2022)

The Congo Red Test for Amyloidosis
Publicado: (1942)

Copper(II) Binding to α-Synuclein, the Parkinson’s Protein
por: Lee, Jennifer C., et al.
Publicado: (2008)

Molecular Basis of Small-Molecule Binding to α-Synuclein
por: Robustelli, Paul, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_jpt7f84vfuokhkcim7tvidn1t6