RAG-induced DNA double-strand breaks signal through Pim2 to promote pre–B cell survival and limit proliferation

Interleukin 7 (IL-7) promotes pre–B cell survival and proliferation by activating the Pim1 and Akt kinases. These signals must be attenuated to induce G1 cell cycle arrest and expression of the RAG endonuclease, which are both required for IgL chain gene rearrangement. As lost IL-7 signals would lim...

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Detalles Bibliográficos
Autores principales: Bednarski, Jeffrey J., Nickless, Andrew, Bhattacharya, Deepta, Amin, Rupesh H., Schlissel, Mark S., Sleckman, Barry P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2012
Materias:
Brief Definitive Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3260864/
https://www.ncbi.nlm.nih.gov/pubmed/22201128
http://dx.doi.org/10.1084/jem.20112078

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