Loss of the signaling adaptor TRAF1 causes CD8(+) T cell dysregulation during human and murine chronic infection

The signaling adaptor TNFR-associated factor 1 (TRAF1) is specifically lost from virus-specific CD8 T cells during the chronic phase of infection with HIV in humans or lymphocytic choriomeningitis virus (LCMV) clone 13 in mice. In contrast, TRAF1 is maintained at higher levels in virus-specific T ce...

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Detalles Bibliográficos
Autores principales: Wang, Chao, McPherson, Ann J., Jones, R. Brad, Kawamura, Kim S., Lin, Gloria H.Y., Lang, Philipp A., Ambagala, Thanuja, Pellegrini, Marc, Calzascia, Thomas, Aidarus, Nasra, Elford, Alisha R., Yue, Feng Yun, Kremmer, Elisabeth, Kovacs, Colin M., Benko, Erika, Tremblay, Cecile, Routy, Jean-Pierre, Bernard, Nicole F., Ostrowski, Mario A., Ohashi, Pamela S., Watts, Tania H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3260874/
https://www.ncbi.nlm.nih.gov/pubmed/22184633
http://dx.doi.org/10.1084/jem.20110675

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