Cargando…

Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients

A direct association of islet-autoreactive T cells with β cell destruction in human pancreatic islets from type 1 diabetes (T1D) patients has never been demonstrated, and little is known about disease progression after diagnosis. Frozen pancreas samples were obtained from 45 cadaveric T1D donors wit...

Descripción completa

Detalles Bibliográficos
Autores principales:	Coppieters, Ken T., Dotta, Francesco, Amirian, Natalie, Campbell, Peter D., Kay, Thomas W.H., Atkinson, Mark A., Roep, Bart O., von Herrath, Matthias G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3260877/ https://www.ncbi.nlm.nih.gov/pubmed/22213807 http://dx.doi.org/10.1084/jem.20111187

Ejemplares similares

The healthy exocrine pancreas contains preproinsulin-specific CD8 T cells that attack islets in type 1 diabetes
por: Bender, Christine, et al.
Publicado: (2020)

Regulatory T cells control NK cells in an insulitic lesion by depriving them of IL-2
por: Sitrin, Jonathan, et al.
Publicado: (2013)

Functional Redundancy of CXCR3/CXCL10 Signaling in the Recruitment of Diabetogenic Cytotoxic T Lymphocytes to Pancreatic Islets in a Virally Induced Autoimmune Diabetes Model
por: Coppieters, Ken T., et al.
Publicado: (2013)

A Novel Technique for the In Vivo Imaging of Autoimmune Diabetes Development in the Pancreas by Two-Photon Microscopy
por: Coppieters, Ken, et al.
Publicado: (2010)

Tolerogenic dendritic cells pulsed with islet antigen induce long-term reduction in T-cell autoreactivity in type 1 diabetes patients
por: Nikolic, Tatjana, et al.
Publicado: (2022)

Simultaneous Detection of Circulating Autoreactive CD8(+) T-Cells Specific for Different Islet Cell–Associated Epitopes Using Combinatorial MHC Multimers
por: Velthuis, Jurjen H., et al.
Publicado: (2010)

Differences in Baseline Lymphocyte Counts and Autoreactivity Are Associated With Differences in Outcome of Islet Cell Transplantation in Type 1 Diabetic Patients
por: Hilbrands, Robert, et al.
Publicado: (2009)

Self-Glycolipids Modulate Dendritic Cells Changing the Cytokine Profiles of Committed Autoreactive T Cells
por: Buschard, Karsten, et al.
Publicado: (2012)

The Immunoreactive Platform of the Pancreatic Islets Influences the Development of Autoreactivity
por: Unanue, Emil R., et al.
Publicado: (2019)

Islet stress, degradation and autoimmunity
por: Thomaidou, Sofia, et al.
Publicado: (2018)

Islet-Resident Dendritic Cells and Macrophages in Type 1 Diabetes: In Search of Bigfoot’s Print
por: Zirpel, Henner, et al.
Publicado: (2021)

New Insights Into the Role of Autoreactive CD8 T Cells and Cytokines in Human Type 1 Diabetes
por: Bender, Christine, et al.
Publicado: (2021)

Current Advances and Travails in Islet Transplantation
por: Harlan, David M., et al.
Publicado: (2009)

The Development of Immunotherapy Strategies for the Treatment of Type 1 Diabetes
por: Coppieters, Ken, et al.
Publicado: (2018)

Clinical and genetic correlates of islet-autoimmune signatures in juvenile-onset type 1 diabetes
por: Claessens, Laura A., et al.
Publicado: (2019)

In Autoimmune Diabetes Unique Autoreactive T Cells Recognize Insulin Peptides Generated in the Islets of Langerhans
por: Mohan, James F., et al.
Publicado: (2010)

Metabolic syndrome – Removing roadblocks to therapy: Antigenic immunotherapies()
por: Coppieters, Ken T., et al.
Publicado: (2014)

The Type 1 Diabetes Signature: Hardwired to Trigger Inflammation?
por: Coppieters, Ken T., et al.
Publicado: (2014)

Validity and Reproducibility of Measurement of Islet Autoreactivity by T-Cell Assays in Subjects With Early Type 1 Diabetes
por: Herold, Kevan C., et al.
Publicado: (2009)

Activation of Islet Autoreactive Naïve T Cells in Infants Is Influenced by Homeostatic Mechanisms and Antigen-Presenting Capacity
por: Heninger, Anne-Kristin, et al.
Publicado: (2013)

Induction of autoreactive B cells allows priming of autoreactive T cells
Publicado: (1991)

Combination Therapy With an Anti–IL-1β Antibody and GAD65 DNA Vaccine Can Reverse Recent-Onset Diabetes in the RIP-GP Mouse Model
por: Pagni, Philippe P., et al.
Publicado: (2014)

Increase in Pancreatic Proinsulin and Preservation of β-Cell Mass in Autoantibody-Positive Donors Prior to Type 1 Diabetes Onset
por: Rodriguez-Calvo, Teresa, et al.
Publicado: (2017)

Human islet T cells are highly reactive to preproinsulin in type 1 diabetes
por: Anderson, Amanda M., et al.
Publicado: (2021)

Genetic correlates of autoreactivity and autoreactive potential in human Ig heavy chains
por: Volpe, Joseph M, et al.
Publicado: (2009)

GAD-alum immunotherapy in type 1 diabetes expands bifunctional Th1/Th2 autoreactive CD4 T cells
por: Arif, Sefina, et al.
Publicado: (2020)

Navigating diabetes-related immune epitope data: resources and tools provided by the Immune Epitope Database (IEDB)
por: Vaughan, Kerrie, et al.
Publicado: (2013)

IL-21 regulates SOCS1 expression in autoreactive CD8(+) T cells but is not required for acquisition of CTL activity in the islets of non-obese diabetic mice
por: Sutherland, Andrew P. R., et al.
Publicado: (2019)

Autoreactive HSP60 epitope-specific T-cells in early human atherosclerotic lesions
por: Almanzar, Giovanni, et al.
Publicado: (2012)

Neuronal T-Cell Autoreactivity Is Amplified in Overweight Children With New-Onset Insulin-Requiring Diabetes
por: Buryk, Melissa A., et al.
Publicado: (2015)

Arrest in the Progression of Type 1 Diabetes at the Mid-Stage of Insulitic Autoimmunity Using an Autoantigen-Decorated All-trans Retinoic Acid and Transforming Growth Factor Beta-1 Single Microparticle Formulation
por: Phillips, Brett E., et al.
Publicado: (2021)

Syntaxin 4 Expression in Pancreatic β-Cells Promotes Islet Function and Protects Functional β-Cell Mass
por: Oh, Eunjin, et al.
Publicado: (2018)

Cellular Islet Autoimmunity Associates with Clinical Outcome of Islet Cell Transplantation
por: Huurman, Volkert A. L., et al.
Publicado: (2008)

The secret autoreactivity of B cells
por: Williams, Ruth
Publicado: (2007)

Autoreactivity patterns in rheumatoid arthritis
por: Behrens, S, et al.
Publicado: (2001)

The broad spectrum of pathogenic autoreactivity
por: Santambrogio, Laura, et al.
Publicado: (2022)

Increased Expression of Viral Sensor MDA5 in Pancreatic Islets and in Hormone-Negative Endocrine Cells in Recent Onset Type 1 Diabetic Donors
por: Nigi, Laura, et al.
Publicado: (2022)

Peripheral autoreactive CD8 T‐cell frequencies are too variable to be a reliable predictor of disease progression of human type 1 diabetes
por: Wesley, Johnna D, et al.
Publicado: (2021)

Non-antigenic and antigenic interventions in type 1 diabetes
por: Rydén, Anna KE, et al.
Publicado: (2013)

Increased Immune Cell Infiltration of the Exocrine Pancreas: A Possible Contribution to the Pathogenesis of Type 1 Diabetes
por: Rodriguez-Calvo, Teresa, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_rvg5d1hu2fh8poo74k8u5kjpm8