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Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients

A direct association of islet-autoreactive T cells with β cell destruction in human pancreatic islets from type 1 diabetes (T1D) patients has never been demonstrated, and little is known about disease progression after diagnosis. Frozen pancreas samples were obtained from 45 cadaveric T1D donors wit...

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Detalles Bibliográficos
Autores principales:	Coppieters, Ken T., Dotta, Francesco, Amirian, Natalie, Campbell, Peter D., Kay, Thomas W.H., Atkinson, Mark A., Roep, Bart O., von Herrath, Matthias G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2012
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3260877/ https://www.ncbi.nlm.nih.gov/pubmed/22213807 http://dx.doi.org/10.1084/jem.20111187

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