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Pilot in vivo toxicological investigation of boron nitride nanotubes

Boron nitride nanotubes (BNNTs) have attracted huge attention in many different research fields thanks to their outstanding chemical and physical properties. During recent years, our group has pioneered the use of BNNTs for biomedical applications, first of all assessing their in vitro cytocompatibi...

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Autores principales: Ciofani, Gianni, Danti, Serena, Genchi, Giada Graziana, D’Alessandro, Delfo, Pellequer, Jean-Luc, Odorico, Michaël, Mattoli, Virgilio, Giorgi, Mario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3260947/
https://www.ncbi.nlm.nih.gov/pubmed/22275819
http://dx.doi.org/10.2147/IJN.S28144
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author Ciofani, Gianni
Danti, Serena
Genchi, Giada Graziana
D’Alessandro, Delfo
Pellequer, Jean-Luc
Odorico, Michaël
Mattoli, Virgilio
Giorgi, Mario
author_facet Ciofani, Gianni
Danti, Serena
Genchi, Giada Graziana
D’Alessandro, Delfo
Pellequer, Jean-Luc
Odorico, Michaël
Mattoli, Virgilio
Giorgi, Mario
author_sort Ciofani, Gianni
collection PubMed
description Boron nitride nanotubes (BNNTs) have attracted huge attention in many different research fields thanks to their outstanding chemical and physical properties. During recent years, our group has pioneered the use of BNNTs for biomedical applications, first of all assessing their in vitro cytocompatibility on many different cell lines. At this point, in vivo investigations are necessary before proceeding toward realistic developments of the proposed applications. In this communication, we report a pilot toxicological study of BNNTs in rabbits. Animals were injected with a 1 mg/kg BNNT solution and blood tests were performed up to 72 hours after injection. The analyses aimed at evaluating any acute alteration of hematic parameters that could represent evidence of functional impairment in blood, liver, and kidneys. Even if preliminary, the data are highly promising, as they showed no adverse effects on all the evaluated parameters, and therefore suggest the possibility of the realistic application of BNNTs in the biomedical field.
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spelling pubmed-32609472012-01-24 Pilot in vivo toxicological investigation of boron nitride nanotubes Ciofani, Gianni Danti, Serena Genchi, Giada Graziana D’Alessandro, Delfo Pellequer, Jean-Luc Odorico, Michaël Mattoli, Virgilio Giorgi, Mario Int J Nanomedicine Rapid Communication Boron nitride nanotubes (BNNTs) have attracted huge attention in many different research fields thanks to their outstanding chemical and physical properties. During recent years, our group has pioneered the use of BNNTs for biomedical applications, first of all assessing their in vitro cytocompatibility on many different cell lines. At this point, in vivo investigations are necessary before proceeding toward realistic developments of the proposed applications. In this communication, we report a pilot toxicological study of BNNTs in rabbits. Animals were injected with a 1 mg/kg BNNT solution and blood tests were performed up to 72 hours after injection. The analyses aimed at evaluating any acute alteration of hematic parameters that could represent evidence of functional impairment in blood, liver, and kidneys. Even if preliminary, the data are highly promising, as they showed no adverse effects on all the evaluated parameters, and therefore suggest the possibility of the realistic application of BNNTs in the biomedical field. Dove Medical Press 2012 2012-01-04 /pmc/articles/PMC3260947/ /pubmed/22275819 http://dx.doi.org/10.2147/IJN.S28144 Text en © 2012 Ciofani et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.
spellingShingle Rapid Communication
Ciofani, Gianni
Danti, Serena
Genchi, Giada Graziana
D’Alessandro, Delfo
Pellequer, Jean-Luc
Odorico, Michaël
Mattoli, Virgilio
Giorgi, Mario
Pilot in vivo toxicological investigation of boron nitride nanotubes
title Pilot in vivo toxicological investigation of boron nitride nanotubes
title_full Pilot in vivo toxicological investigation of boron nitride nanotubes
title_fullStr Pilot in vivo toxicological investigation of boron nitride nanotubes
title_full_unstemmed Pilot in vivo toxicological investigation of boron nitride nanotubes
title_short Pilot in vivo toxicological investigation of boron nitride nanotubes
title_sort pilot in vivo toxicological investigation of boron nitride nanotubes
topic Rapid Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3260947/
https://www.ncbi.nlm.nih.gov/pubmed/22275819
http://dx.doi.org/10.2147/IJN.S28144
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