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Pilot in vivo toxicological investigation of boron nitride nanotubes
Boron nitride nanotubes (BNNTs) have attracted huge attention in many different research fields thanks to their outstanding chemical and physical properties. During recent years, our group has pioneered the use of BNNTs for biomedical applications, first of all assessing their in vitro cytocompatibi...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3260947/ https://www.ncbi.nlm.nih.gov/pubmed/22275819 http://dx.doi.org/10.2147/IJN.S28144 |
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author | Ciofani, Gianni Danti, Serena Genchi, Giada Graziana D’Alessandro, Delfo Pellequer, Jean-Luc Odorico, Michaël Mattoli, Virgilio Giorgi, Mario |
author_facet | Ciofani, Gianni Danti, Serena Genchi, Giada Graziana D’Alessandro, Delfo Pellequer, Jean-Luc Odorico, Michaël Mattoli, Virgilio Giorgi, Mario |
author_sort | Ciofani, Gianni |
collection | PubMed |
description | Boron nitride nanotubes (BNNTs) have attracted huge attention in many different research fields thanks to their outstanding chemical and physical properties. During recent years, our group has pioneered the use of BNNTs for biomedical applications, first of all assessing their in vitro cytocompatibility on many different cell lines. At this point, in vivo investigations are necessary before proceeding toward realistic developments of the proposed applications. In this communication, we report a pilot toxicological study of BNNTs in rabbits. Animals were injected with a 1 mg/kg BNNT solution and blood tests were performed up to 72 hours after injection. The analyses aimed at evaluating any acute alteration of hematic parameters that could represent evidence of functional impairment in blood, liver, and kidneys. Even if preliminary, the data are highly promising, as they showed no adverse effects on all the evaluated parameters, and therefore suggest the possibility of the realistic application of BNNTs in the biomedical field. |
format | Online Article Text |
id | pubmed-3260947 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-32609472012-01-24 Pilot in vivo toxicological investigation of boron nitride nanotubes Ciofani, Gianni Danti, Serena Genchi, Giada Graziana D’Alessandro, Delfo Pellequer, Jean-Luc Odorico, Michaël Mattoli, Virgilio Giorgi, Mario Int J Nanomedicine Rapid Communication Boron nitride nanotubes (BNNTs) have attracted huge attention in many different research fields thanks to their outstanding chemical and physical properties. During recent years, our group has pioneered the use of BNNTs for biomedical applications, first of all assessing their in vitro cytocompatibility on many different cell lines. At this point, in vivo investigations are necessary before proceeding toward realistic developments of the proposed applications. In this communication, we report a pilot toxicological study of BNNTs in rabbits. Animals were injected with a 1 mg/kg BNNT solution and blood tests were performed up to 72 hours after injection. The analyses aimed at evaluating any acute alteration of hematic parameters that could represent evidence of functional impairment in blood, liver, and kidneys. Even if preliminary, the data are highly promising, as they showed no adverse effects on all the evaluated parameters, and therefore suggest the possibility of the realistic application of BNNTs in the biomedical field. Dove Medical Press 2012 2012-01-04 /pmc/articles/PMC3260947/ /pubmed/22275819 http://dx.doi.org/10.2147/IJN.S28144 Text en © 2012 Ciofani et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited. |
spellingShingle | Rapid Communication Ciofani, Gianni Danti, Serena Genchi, Giada Graziana D’Alessandro, Delfo Pellequer, Jean-Luc Odorico, Michaël Mattoli, Virgilio Giorgi, Mario Pilot in vivo toxicological investigation of boron nitride nanotubes |
title | Pilot in vivo toxicological investigation of boron nitride nanotubes |
title_full | Pilot in vivo toxicological investigation of boron nitride nanotubes |
title_fullStr | Pilot in vivo toxicological investigation of boron nitride nanotubes |
title_full_unstemmed | Pilot in vivo toxicological investigation of boron nitride nanotubes |
title_short | Pilot in vivo toxicological investigation of boron nitride nanotubes |
title_sort | pilot in vivo toxicological investigation of boron nitride nanotubes |
topic | Rapid Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3260947/ https://www.ncbi.nlm.nih.gov/pubmed/22275819 http://dx.doi.org/10.2147/IJN.S28144 |
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