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Clinical development of liposome-based drugs: formulation, characterization, and therapeutic efficacy
Research on liposome formulations has progressed from that on conventional vesicles to new generation liposomes, such as cationic liposomes, temperature sensitive liposomes, and virosomes, by modulating the formulation techniques and lipid composition. Many research papers focus on the correlation o...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3260950/ https://www.ncbi.nlm.nih.gov/pubmed/22275822 http://dx.doi.org/10.2147/IJN.S26766 |
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author | Chang, Hsin-I Yeh, Ming-Kung |
author_facet | Chang, Hsin-I Yeh, Ming-Kung |
author_sort | Chang, Hsin-I |
collection | PubMed |
description | Research on liposome formulations has progressed from that on conventional vesicles to new generation liposomes, such as cationic liposomes, temperature sensitive liposomes, and virosomes, by modulating the formulation techniques and lipid composition. Many research papers focus on the correlation of blood circulation time and drug accumulation in target tissues with physicochemical properties of liposomal formulations, including particle size, membrane lamellarity, surface charge, permeability, encapsulation volume, shelf time, and release rate. This review is mainly to compare the therapeutic effect of current clinically approved liposome-based drugs with free drugs, and to also determine the clinical effect via liposomal variations in lipid composition. Furthermore, the major preclinical and clinical data related to the principal liposomal formulations are also summarized. |
format | Online Article Text |
id | pubmed-3260950 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-32609502012-01-24 Clinical development of liposome-based drugs: formulation, characterization, and therapeutic efficacy Chang, Hsin-I Yeh, Ming-Kung Int J Nanomedicine Review Research on liposome formulations has progressed from that on conventional vesicles to new generation liposomes, such as cationic liposomes, temperature sensitive liposomes, and virosomes, by modulating the formulation techniques and lipid composition. Many research papers focus on the correlation of blood circulation time and drug accumulation in target tissues with physicochemical properties of liposomal formulations, including particle size, membrane lamellarity, surface charge, permeability, encapsulation volume, shelf time, and release rate. This review is mainly to compare the therapeutic effect of current clinically approved liposome-based drugs with free drugs, and to also determine the clinical effect via liposomal variations in lipid composition. Furthermore, the major preclinical and clinical data related to the principal liposomal formulations are also summarized. Dove Medical Press 2012 2011-12-30 /pmc/articles/PMC3260950/ /pubmed/22275822 http://dx.doi.org/10.2147/IJN.S26766 Text en © 2012 Chang and Yeh, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited. |
spellingShingle | Review Chang, Hsin-I Yeh, Ming-Kung Clinical development of liposome-based drugs: formulation, characterization, and therapeutic efficacy |
title | Clinical development of liposome-based drugs: formulation, characterization, and therapeutic efficacy |
title_full | Clinical development of liposome-based drugs: formulation, characterization, and therapeutic efficacy |
title_fullStr | Clinical development of liposome-based drugs: formulation, characterization, and therapeutic efficacy |
title_full_unstemmed | Clinical development of liposome-based drugs: formulation, characterization, and therapeutic efficacy |
title_short | Clinical development of liposome-based drugs: formulation, characterization, and therapeutic efficacy |
title_sort | clinical development of liposome-based drugs: formulation, characterization, and therapeutic efficacy |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3260950/ https://www.ncbi.nlm.nih.gov/pubmed/22275822 http://dx.doi.org/10.2147/IJN.S26766 |
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