Polymeric micelles based on poly(ethylene glycol) block poly(racemic amino acids) hybrid polypeptides: conformation-facilitated drug-loading behavior and potential application as effective anticancer drug carriers

In this work, racemic hybrid polypeptides poly(ethylene glycol) (PEG)-b-poly(racemic-leucine) (PRL) copolymers with different leucine residues have been synthesized and characterized. Using docetaxel as a model molecule, the high drug-loaded spherical micelles based on PEG-PRL were prepared successf...

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Detalles Bibliográficos
Autores principales: Gu, Peng Fei, Xu, Hui, Sui, Bo Wen, Gou, Jing Xin, Meng, Ling Kuo, Sun, Feng, Wang, Xiu Jun, Qi, Na, Zhang, Yu, He, Hai Bing, Tang, Xing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2012
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3260955/
https://www.ncbi.nlm.nih.gov/pubmed/22275827
http://dx.doi.org/10.2147/IJN.S27475

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