Cargando…

SimReg1 is a master switch for biosynthesis and export of simocyclinone D8 and its precursors

Analysis of the simocyclinone biosynthesis (sim) gene cluster of Streptomyces antibioticus Tü6040 led to the identification of a putative pathway specific regulatory gene simReg1. In silico analysis places the SimReg1 protein in the OmpR-PhoB subfamily of response regulators. Gene replacement of sim...

Descripción completa

Detalles Bibliográficos
Autores principales:	Horbal, Liliya, Rebets, Yuriy, Rabyk, Mariya, Makitrynskyy, Roman, Luzhetskyy, Andriy, Fedorenko, Victor, Bechthold, Andreas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer 2012
Materias:	Original
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3261101/ https://www.ncbi.nlm.nih.gov/pubmed/22214346 http://dx.doi.org/10.1186/2191-0855-2-1

Ejemplares similares

Pleiotropic regulatory genes bldA, adpA and absB are implicated in production of phosphoglycolipid antibiotic moenomycin
por: Makitrynskyy, Roman, et al.
Publicado: (2013)

Chromosomal position effect influences the heterologous expression of genes and biosynthetic gene clusters in Streptomyces albus J1074
por: Bilyk, Bohdan, et al.
Publicado: (2017)

Insights into naturally minimised Streptomyces albus J1074 genome
por: Zaburannyi, Nestor, et al.
Publicado: (2014)

Complete genome sequence of producer of the glycopeptide antibiotic Aculeximycin Kutzneria albida DSM 43870(T), a representative of minor genus of Pseudonocardiaceae
por: Rebets, Yuriy, et al.
Publicado: (2014)

Discovery and overproduction of novel highly bioactive pamamycins through transcriptional engineering of the biosynthetic gene cluster
por: Eckert, Nikolas, et al.
Publicado: (2023)

SimC7 Is a Novel NAD(P)H-Dependent Ketoreductase Essential for the Antibiotic Activity of the DNA Gyrase Inhibitor Simocyclinone
por: Schäfer, Martin, et al.
Publicado: (2015)

Structural insights into simocyclinone as an antibiotic, effector ligand and substrate
por: Buttner, Mark J, et al.
Publicado: (2017)

Cyclofaulknamycin with the Rare Amino Acid D-capreomycidine Isolated from a Well-Characterized Streptomyces albus Strain
por: Horbal, Liliya, et al.
Publicado: (2021)

Identification of butenolide regulatory system controlling secondary metabolism in Streptomyces albus J1074
por: Ahmed, Yousra, et al.
Publicado: (2017)

Targeted Genome Mining—From Compound Discovery to Biosynthetic Pathway Elucidation
por: Gummerlich, Nils, et al.
Publicado: (2020)

A set of synthetic versatile genetic control elements for the efficient expression of genes in Actinobacteria
por: Horbal, Lilya, et al.
Publicado: (2018)

New Alpiniamides From Streptomyces sp. IB2014/011-12 Assembled by an Unusual Hybrid Non-ribosomal Peptide Synthetase Trans-AT Polyketide Synthase Enzyme
por: Paulus, Constanze, et al.
Publicado: (2018)

Engineering of Streptomyces lividans for heterologous expression of secondary metabolite gene clusters
por: Ahmed, Yousra, et al.
Publicado: (2020)

Revealing Genome-Based Biosynthetic Potential of Streptomyces sp. BR123 Isolated from Sunflower Rhizosphere with Broad Spectrum Antimicrobial Activity
por: Ashraf, Neelma, et al.
Publicado: (2022)

Dual control system – A novel scaffolding architecture of an inducible regulatory device for the precise regulation of gene expression
por: Horbal, L., et al.
Publicado: (2016)

Characterization of Sigma Factor Genes in Streptomyces lividans TK24 Using a Genomic Library-Based Approach for Multiple Gene Deletions
por: Rebets, Yuriy, et al.
Publicado: (2018)

Genetic Engineering of Streptomyces ghanaensis ATCC14672 for Improved Production of Moenomycins
por: Makitrynskyy, Roman, et al.
Publicado: (2021)

Mastering Import and Export Management
por: Cook, Thomas
Publicado: (2017)

Cyclic di-GMP cyclase SSFG_02181 from Streptomyces ghanaensis ATCC14672 regulates antibiotic biosynthesis and morphological differentiation in streptomycetes
por: Nuzzo, Desirèe, et al.
Publicado: (2020)

Identification and Characterization of Four c-di-GMP-Metabolizing Enzymes from Streptomyces ghanaensis ATCC14672 Involved in the Regulation of Morphogenesis and Moenomycin A Biosynthesis
por: Nuzzo, Desirèe, et al.
Publicado: (2021)

Diversity and bioactive potential of Actinomycetia from the rhizosphere soil of Juniperus excelsa
por: Tistechok, Stepan, et al.
Publicado: (2023)

Antibacterial Discovery and Development: From Gene to Product and Back
por: Fedorenko, Victor, et al.
Publicado: (2015)

A New Crystal Structure of the Bifunctional Antibiotic Simocyclinone D8 Bound to DNA Gyrase Gives Fresh Insight into the Mechanism of Inhibition
por: Hearnshaw, Stephen J., et al.
Publicado: (2014)

Actinobacteria Isolated from an Underground Lake and Moonmilk Speleothem from the Biggest Conglomeratic Karstic Cave in Siberia as Sources of Novel Biologically Active Compounds
por: Axenov-Gibanov, Denis V., et al.
Publicado: (2016)

Correction: Actinobacteria Isolated from an Underground Lake and Moonmilk Speleothem from the Biggest Conglomeratic Karstic Cave in Siberia as Sources of Novel Biologically Active Compounds
por: Axenov-Gribanov, Denis V., et al.
Publicado: (2016)

Draft Genome Sequence of Streptomyces sp. Strain IB2014011-1, Isolated from Trichoptera sp. Larvae of Lake Baikal
por: Axenov-Gribanov, Denis V., et al.
Publicado: (2017)

RegAB Homolog of Burkholderia pseudomallei is the Master Regulator of Redox Control and involved in Virulence
por: Phenn, Julia, et al.
Publicado: (2021)

New natural products identified by combined genomics-metabolomics profiling of marine Streptomyces sp. MP131-18
por: Paulus, Constanze, et al.
Publicado: (2017)

Baikalomycins A-C, New Aquayamycin-Type Angucyclines Isolated from Lake Baikal Derived Streptomyces sp. IB201691-2A
por: Voitsekhovskaia, Irina, et al.
Publicado: (2020)

Secondary nucleotide messenger c-di-GMP exerts a global control on natural product biosynthesis in streptomycetes
por: Makitrynskyy, Roman, et al.
Publicado: (2020)

Regulatory Control of Rishirilide(s) Biosynthesis in Streptomyces bottropensis
por: Tsypik, Olga, et al.
Publicado: (2021)

Specialization of the Drosophila nuclear export family protein Nxf3 for piRNA precursor export
por: Kneuss, Emma, et al.
Publicado: (2019)

Mastering Redmine
por: Lesyuk, Andriy
Publicado: (2013)

Role of export industries on ozone pollution and its precursors in China
por: Ou, Jiamin, et al.
Publicado: (2020)

Role of GntR Family Regulatory Gene SCO1678 in Gluconate Metabolism in Streptomyces coelicolor M145
por: Tsypik, Olga, et al.
Publicado: (2017)

Multi-Omics and Targeted Approaches to Determine the Role of Cellular Proteases in Streptomyces Protein Secretion
por: Busche, Tobias, et al.
Publicado: (2018)

Detector Simulation (FastSim and Full Sim etc.)
por: Jeans, Daniel
Publicado: (2021)

Controversial Canadian regs.
por: Fields, S
Publicado: (2001)

The mark of T reg cells
por: Van Epps, Heather L.
Publicado: (2005)

New target for T regs
por: Van Epps, Heather L.
Publicado: (2005)

Cannot write session to /tmp/vufind_sessions/sess_tcqlkm7lov5mb0khjd0tiapl33