Mitochondrial Apoptosis and FAK Signaling Disruption by a Novel Histone Deacetylase Inhibitor, HTPB, in Antitumor and Antimetastatic Mouse Models

BACKGROUND: Compound targeting histone deacetylase (HDAC) represents a new era in molecular cancer therapeutics. However, effective HDAC inhibitors for the treatment of solid tumors remain to be developed. METHODOLOGY/PRINCIPAL FINDINGS: Here, we propose a novel HDAC inhibitor, N-Hydroxy-4-(4-phenyl...

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Detalles Bibliográficos
Autores principales: Shieh, Jiunn-Min, Wei, Tzu-Tang, Tang, Yen-An, Huang, Sin-Ming, Wen, Wei-Ling, Chen, Mei-Yu, Cheng, Hung-Chi, Salunke, Santosh B., Chen, Ching-Shih, Lin, Pinpin, Chen, Chien-Tien, Wang, Yi-Ching
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3261198/
https://www.ncbi.nlm.nih.gov/pubmed/22279574
http://dx.doi.org/10.1371/journal.pone.0030240

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