Cargando…
Prader–Willi syndrome and autism spectrum disorders: an evolving story
Prader–Willi syndrome (PWS) is well-known for its genetic and phenotypic complexities. Caused by a lack of paternally derived imprinted material on chromosome 15q11–q13, individuals with PWS have mild to moderate intellectual disabilities, repetitive and compulsive behaviors, skin picking, tantrums,...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2011
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3261277/ https://www.ncbi.nlm.nih.gov/pubmed/21858456 http://dx.doi.org/10.1007/s11689-011-9092-5 |
_version_ | 1782221581275103232 |
---|---|
author | Dykens, Elisabeth M. Lee, Evon Roof, Elizabeth |
author_facet | Dykens, Elisabeth M. Lee, Evon Roof, Elizabeth |
author_sort | Dykens, Elisabeth M. |
collection | PubMed |
description | Prader–Willi syndrome (PWS) is well-known for its genetic and phenotypic complexities. Caused by a lack of paternally derived imprinted material on chromosome 15q11–q13, individuals with PWS have mild to moderate intellectual disabilities, repetitive and compulsive behaviors, skin picking, tantrums, irritability, hyperphagia, and increased risks of obesity. Many individuals also have co-occurring autism spectrum disorders (ASDs), psychosis, and mood disorders. Although the PWS 15q11–q13 region confers risks for autism, relatively few studies have assessed autism symptoms in PWS or directly compared social, behavioral, and cognitive functioning across groups with autism or PWS. This article identifies areas of phenotypic overlap and difference between PWS and ASD in core autism symptoms and in such comorbidities as psychiatric disorders, and dysregulated sleep and eating. Though future studies are needed, PWS provides a promising alternative lens into specific symptoms and comorbidities of autism. |
format | Online Article Text |
id | pubmed-3261277 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-32612772012-01-19 Prader–Willi syndrome and autism spectrum disorders: an evolving story Dykens, Elisabeth M. Lee, Evon Roof, Elizabeth J Neurodev Disord Article Prader–Willi syndrome (PWS) is well-known for its genetic and phenotypic complexities. Caused by a lack of paternally derived imprinted material on chromosome 15q11–q13, individuals with PWS have mild to moderate intellectual disabilities, repetitive and compulsive behaviors, skin picking, tantrums, irritability, hyperphagia, and increased risks of obesity. Many individuals also have co-occurring autism spectrum disorders (ASDs), psychosis, and mood disorders. Although the PWS 15q11–q13 region confers risks for autism, relatively few studies have assessed autism symptoms in PWS or directly compared social, behavioral, and cognitive functioning across groups with autism or PWS. This article identifies areas of phenotypic overlap and difference between PWS and ASD in core autism symptoms and in such comorbidities as psychiatric disorders, and dysregulated sleep and eating. Though future studies are needed, PWS provides a promising alternative lens into specific symptoms and comorbidities of autism. Springer US 2011-08-20 2011-09 /pmc/articles/PMC3261277/ /pubmed/21858456 http://dx.doi.org/10.1007/s11689-011-9092-5 Text en © Springer Science+Business Media, LLC 2011 |
spellingShingle | Article Dykens, Elisabeth M. Lee, Evon Roof, Elizabeth Prader–Willi syndrome and autism spectrum disorders: an evolving story |
title | Prader–Willi syndrome and autism spectrum disorders: an evolving story |
title_full | Prader–Willi syndrome and autism spectrum disorders: an evolving story |
title_fullStr | Prader–Willi syndrome and autism spectrum disorders: an evolving story |
title_full_unstemmed | Prader–Willi syndrome and autism spectrum disorders: an evolving story |
title_short | Prader–Willi syndrome and autism spectrum disorders: an evolving story |
title_sort | prader–willi syndrome and autism spectrum disorders: an evolving story |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3261277/ https://www.ncbi.nlm.nih.gov/pubmed/21858456 http://dx.doi.org/10.1007/s11689-011-9092-5 |
work_keys_str_mv | AT dykenselisabethm praderwillisyndromeandautismspectrumdisordersanevolvingstory AT leeevon praderwillisyndromeandautismspectrumdisordersanevolvingstory AT roofelizabeth praderwillisyndromeandautismspectrumdisordersanevolvingstory |