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Rifampicin Does not Significantly Affect the Expression of Small Heterodimer Partner in Primary Human Hepatocytes

The small/short heterodimer partner (SHP, NR0B2) is a nuclear receptor corepressor lacking a DNA binding domain. SHP is induced by bile acid-activated farnesoid X receptor (FXR) resulting in CYP7A1 gene suppression. In contrast, Pregnane X receptor (PXR) activation by its ligands was recently sugges...

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Detalles Bibliográficos
Autores principales:	Pavek, Petr, Stejskalova, Lucie, Krausova, Lucie, Bitman, Michal, Vrzal, Radim, Dvorak, Zdenek
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Research Foundation 2012
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3261431/ https://www.ncbi.nlm.nih.gov/pubmed/22291651 http://dx.doi.org/10.3389/fphar.2012.00001

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