The role of EZH2 in tumour progression

Accumulated evidence shows that EZH2 is deregulated in a wide range of cancer types, and it has a crucial role in stem cell maintenance and tumour development. Therefore, blocking EZH2 expression or activity may represent a promising strategy for anticancer treatment. In this review, we address the...

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Detalles Bibliográficos
Autores principales: Chang, C-J, Hung, M-C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Minireview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3261672/
https://www.ncbi.nlm.nih.gov/pubmed/22187039
http://dx.doi.org/10.1038/bjc.2011.551
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author Chang, C-J
Hung, M-C
author_facet Chang, C-J
Hung, M-C
author_sort Chang, C-J
collection PubMed
description Accumulated evidence shows that EZH2 is deregulated in a wide range of cancer types, and it has a crucial role in stem cell maintenance and tumour development. Therefore, blocking EZH2 expression or activity may represent a promising strategy for anticancer treatment. In this review, we address the current understanding of the mechanisms underlying EZH2 regulation alongside the function of EZH2 gene targets that are involved in cancer progression. Finally, we will describe cancer therapies that target EZH2 or its downstream cascades, which could potentially reverse the oncogenic and stemness properties of the tumour cells to suppress cancer progression and recurrence.
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spelling pubmed-32616722013-01-17 The role of EZH2 in tumour progression Chang, C-J Hung, M-C Br J Cancer Minireview Accumulated evidence shows that EZH2 is deregulated in a wide range of cancer types, and it has a crucial role in stem cell maintenance and tumour development. Therefore, blocking EZH2 expression or activity may represent a promising strategy for anticancer treatment. In this review, we address the current understanding of the mechanisms underlying EZH2 regulation alongside the function of EZH2 gene targets that are involved in cancer progression. Finally, we will describe cancer therapies that target EZH2 or its downstream cascades, which could potentially reverse the oncogenic and stemness properties of the tumour cells to suppress cancer progression and recurrence. Nature Publishing Group 2012-01-17 2011-12-20 /pmc/articles/PMC3261672/ /pubmed/22187039 http://dx.doi.org/10.1038/bjc.2011.551 Text en Copyright © 2012 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Minireview
Chang, C-J
Hung, M-C
The role of EZH2 in tumour progression
title The role of EZH2 in tumour progression
title_full The role of EZH2 in tumour progression
title_fullStr The role of EZH2 in tumour progression
title_full_unstemmed The role of EZH2 in tumour progression
title_short The role of EZH2 in tumour progression
title_sort role of ezh2 in tumour progression
topic Minireview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3261672/
https://www.ncbi.nlm.nih.gov/pubmed/22187039
http://dx.doi.org/10.1038/bjc.2011.551
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