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The anticancer effects of chaetocin are independent of programmed cell death and hypoxia, and are associated with inhibition of endothelial cell proliferation

BACKGROUND: We previously reported that chaetocin has potent and selective anti-myeloma activity attributable to reactive oxygen species (ROS) induction imposed by inhibition of the redox enzyme thioredoxin reductase; we now detail its effects in solid tumours. METHODS: Cellular assays, transcriptio...

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Detalles Bibliográficos
Autores principales:	Isham, C R, Tibodeau, J D, Bossou, A R, Merchan, J R, Bible, K C
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2012
Materias:	Translational Therapeutics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3261675/ https://www.ncbi.nlm.nih.gov/pubmed/22187030 http://dx.doi.org/10.1038/bjc.2011.522

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