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Crucial roles for DNA ligase III in mitochondria but not in XRCC1-dependent repair

Mammalian cells have 3 ATP-dependent DNA ligases, which are required for DNA replication and repair(1). Homologs of ligase I (Lig1) and ligase IV (Lig4) are ubiquitous in eukarya, whereas ligase III (Lig3), which has nuclear and mitochondrial forms, appears to be restricted to vertebrates. Lig3 is i...

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Detalles Bibliográficos
Autores principales:	Simsek, Deniz, Furda, Amy, Gao, Yankun, Artus, Jérôme, Brunet, Erika, Hadjantonakis, Anna-Katerina, Van Houten, Bennett, Shuman, Stewart, McKinnon, Peter J., Jasin, Maria
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2011
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3261757/ https://www.ncbi.nlm.nih.gov/pubmed/21390132 http://dx.doi.org/10.1038/nature09794

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