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Association between chronic viral hepatitis infection and breast cancer risk: a nationwide population-based case-control study
BACKGROUND: In Taiwan, there is a high incidence of breast cancer and a high prevalence of viral hepatitis. In this case-control study, we used a population-based insurance dataset to evaluate whether breast cancer in women is associated with chronic viral hepatitis infection. METHODS: From the clai...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3261833/ https://www.ncbi.nlm.nih.gov/pubmed/22115285 http://dx.doi.org/10.1186/1471-2407-11-495 |
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author | Su, Fu-Hsiung Chang, Shih-Ni Chen, Pei-Chun Sung, Fung-Chang Su, Chien-Tien Yeh, Chih-Ching |
author_facet | Su, Fu-Hsiung Chang, Shih-Ni Chen, Pei-Chun Sung, Fung-Chang Su, Chien-Tien Yeh, Chih-Ching |
author_sort | Su, Fu-Hsiung |
collection | PubMed |
description | BACKGROUND: In Taiwan, there is a high incidence of breast cancer and a high prevalence of viral hepatitis. In this case-control study, we used a population-based insurance dataset to evaluate whether breast cancer in women is associated with chronic viral hepatitis infection. METHODS: From the claims data, we identified 1,958 patients with newly diagnosed breast cancer during the period 2000-2008. A randomly selected, age-matched cohort of 7,832 subjects without cancer was selected for comparison. Multivariable logistic regression models were constructed to calculate odds ratios of breast cancer associated with viral hepatitis after adjustment for age, residential area, occupation, urbanization, and income. The age-specific (<50 years and ≥50 years) risk of breast cancer was also evaluated. RESULTS: There were no significant differences in the prevalence of hepatitis C virus (HCV) infection, hepatitis B virus (HBV), or the prevalence of combined HBC/HBV infection between breast cancer patients and control subjects (p = 0.48). Multivariable logistic regression analysis, however, revealed that age <50 years was associated with a 2-fold greater risk of developing breast cancer (OR = 2.03, 95% CI = 1.23-3.34). CONCLUSIONS: HCV infection, but not HBV infection, appears to be associated with early onset risk of breast cancer in areas endemic for HCV and HBV. This finding needs to be replicated in further studies. |
format | Online Article Text |
id | pubmed-3261833 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-32618332012-01-20 Association between chronic viral hepatitis infection and breast cancer risk: a nationwide population-based case-control study Su, Fu-Hsiung Chang, Shih-Ni Chen, Pei-Chun Sung, Fung-Chang Su, Chien-Tien Yeh, Chih-Ching BMC Cancer Research Article BACKGROUND: In Taiwan, there is a high incidence of breast cancer and a high prevalence of viral hepatitis. In this case-control study, we used a population-based insurance dataset to evaluate whether breast cancer in women is associated with chronic viral hepatitis infection. METHODS: From the claims data, we identified 1,958 patients with newly diagnosed breast cancer during the period 2000-2008. A randomly selected, age-matched cohort of 7,832 subjects without cancer was selected for comparison. Multivariable logistic regression models were constructed to calculate odds ratios of breast cancer associated with viral hepatitis after adjustment for age, residential area, occupation, urbanization, and income. The age-specific (<50 years and ≥50 years) risk of breast cancer was also evaluated. RESULTS: There were no significant differences in the prevalence of hepatitis C virus (HCV) infection, hepatitis B virus (HBV), or the prevalence of combined HBC/HBV infection between breast cancer patients and control subjects (p = 0.48). Multivariable logistic regression analysis, however, revealed that age <50 years was associated with a 2-fold greater risk of developing breast cancer (OR = 2.03, 95% CI = 1.23-3.34). CONCLUSIONS: HCV infection, but not HBV infection, appears to be associated with early onset risk of breast cancer in areas endemic for HCV and HBV. This finding needs to be replicated in further studies. BioMed Central 2011-11-24 /pmc/articles/PMC3261833/ /pubmed/22115285 http://dx.doi.org/10.1186/1471-2407-11-495 Text en Copyright © 2011 Su et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Su, Fu-Hsiung Chang, Shih-Ni Chen, Pei-Chun Sung, Fung-Chang Su, Chien-Tien Yeh, Chih-Ching Association between chronic viral hepatitis infection and breast cancer risk: a nationwide population-based case-control study |
title | Association between chronic viral hepatitis infection and breast cancer risk: a nationwide population-based case-control study |
title_full | Association between chronic viral hepatitis infection and breast cancer risk: a nationwide population-based case-control study |
title_fullStr | Association between chronic viral hepatitis infection and breast cancer risk: a nationwide population-based case-control study |
title_full_unstemmed | Association between chronic viral hepatitis infection and breast cancer risk: a nationwide population-based case-control study |
title_short | Association between chronic viral hepatitis infection and breast cancer risk: a nationwide population-based case-control study |
title_sort | association between chronic viral hepatitis infection and breast cancer risk: a nationwide population-based case-control study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3261833/ https://www.ncbi.nlm.nih.gov/pubmed/22115285 http://dx.doi.org/10.1186/1471-2407-11-495 |
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