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A Novel, “Double-Clamp” Binding Mode for Human Heme Oxygenase-1 Inhibition

The development of heme oxygenase (HO) inhibitors is critical in dissecting and understanding the HO system and for potential therapeutic applications. We have established a program to design and optimize HO inhibitors using structure-activity relationships in conjunction with X-ray crystallographic...

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Detalles Bibliográficos
Autores principales:	Rahman, Mona N., Vlahakis, Jason Z., Vukomanovic, Dragic, Lee, Wallace, Szarek, Walter A., Nakatsu, Kanji, Jia, Zongchao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3261875/ https://www.ncbi.nlm.nih.gov/pubmed/22276118 http://dx.doi.org/10.1371/journal.pone.0029514

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