Structure of S. aureus HPPK and the Discovery of a New Substrate Site Inhibitor

The first structural and biophysical data on the folate biosynthesis pathway enzyme and drug target, 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase (SaHPPK), from the pathogen Staphylococcus aureus is presented. HPPK is the second essential enzyme in the pathway catalysing the pyrophosphoryl tr...

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Detalles Bibliográficos
Autores principales: Chhabra, Sandeep, Dolezal, Olan, Collins, Brett M., Newman, Janet, Simpson, Jamie S., Macreadie, Ian G., Fernley, Ross, Peat, Thomas S., Swarbrick, James D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3261883/
https://www.ncbi.nlm.nih.gov/pubmed/22276115
http://dx.doi.org/10.1371/journal.pone.0029444

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3261883/
https://www.ncbi.nlm.nih.gov/pubmed/22276115
http://dx.doi.org/10.1371/journal.pone.0029444

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