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Structure of S. aureus HPPK and the Discovery of a New Substrate Site Inhibitor

The first structural and biophysical data on the folate biosynthesis pathway enzyme and drug target, 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase (SaHPPK), from the pathogen Staphylococcus aureus is presented. HPPK is the second essential enzyme in the pathway catalysing the pyrophosphoryl tr...

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Detalles Bibliográficos
Autores principales:	Chhabra, Sandeep, Dolezal, Olan, Collins, Brett M., Newman, Janet, Simpson, Jamie S., Macreadie, Ian G., Fernley, Ross, Peat, Thomas S., Swarbrick, James D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3261883/ https://www.ncbi.nlm.nih.gov/pubmed/22276115 http://dx.doi.org/10.1371/journal.pone.0029444

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