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Decreased Autocrine EGFR Signaling in Metastatic Breast Cancer Cells Inhibits Tumor Growth in Bone and Mammary Fat Pad

Breast cancer metastasis to bone triggers a vicious cycle of tumor growth linked to osteolysis. Breast cancer cells and osteoblasts express the epidermal growth factor receptor (EGFR) and produce ErbB family ligands, suggesting participation of these growth factors in autocrine and paracrine signali...

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Detalles Bibliográficos
Autores principales: Nickerson, Nicole K., Mohammad, Khalid S., Gilmore, Jennifer L., Crismore, Erin, Bruzzaniti, Angela, Guise, Theresa A., Foley, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3261896/
https://www.ncbi.nlm.nih.gov/pubmed/22276166
http://dx.doi.org/10.1371/journal.pone.0030255