A Spontaneous Mutation of the Rat Themis Gene Leads to Impaired Function of Regulatory T Cells Linked to Inflammatory Bowel Disease

Spontaneous or chemically induced germline mutations, which lead to Mendelian phenotypes, are powerful tools to discover new genes and their functions. Here, we report an autosomal recessive mutation that occurred spontaneously in a Brown-Norway (BN) rat colony and was identified as causing marked T...

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Detalles Bibliográficos
Autores principales: Chabod, Marianne, Pedros, Christophe, Lamouroux, Lucille, Colacios, Céline, Bernard, Isabelle, Lagrange, Dominique, Balz-Hara, Daniela, Mosnier, Jean-Francois, Laboisse, Christian, Vergnolle, Nathalie, Andreoletti, Olivier, Roth, Marie-Paule, Liblau, Roland, Fournié, Gilbert J., Saoudi, Abdelhadi, Dejean, Anne S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3261907/
https://www.ncbi.nlm.nih.gov/pubmed/22275874
http://dx.doi.org/10.1371/journal.pgen.1002461

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