RIC-7 Promotes Neuropeptide Secretion

Secretion of neurotransmitters and neuropeptides is mediated by exocytosis of distinct secretory organelles, synaptic vesicles (SVs) and dense core vesicles (DCVs) respectively. Relatively little is known about factors that differentially regulate SV and DCV secretion. Here we identify a novel prote...

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Detalles Bibliográficos
Autores principales: Hao, Yingsong, Hu, Zhitao, Sieburth, Derek, Kaplan, Joshua M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3261915/
https://www.ncbi.nlm.nih.gov/pubmed/22275875
http://dx.doi.org/10.1371/journal.pgen.1002464
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author Hao, Yingsong
Hu, Zhitao
Sieburth, Derek
Kaplan, Joshua M.
author_facet Hao, Yingsong
Hu, Zhitao
Sieburth, Derek
Kaplan, Joshua M.
author_sort Hao, Yingsong
collection PubMed
description Secretion of neurotransmitters and neuropeptides is mediated by exocytosis of distinct secretory organelles, synaptic vesicles (SVs) and dense core vesicles (DCVs) respectively. Relatively little is known about factors that differentially regulate SV and DCV secretion. Here we identify a novel protein RIC-7 that is required for neuropeptide secretion in Caenorhabditis elegans. The RIC-7 protein is expressed in all neurons and is localized to presynaptic terminals. Imaging, electrophysiology, and behavioral analysis of ric-7 mutants indicates that acetylcholine release occurs normally, while neuropeptide release is significantly decreased. These results suggest that RIC-7 promotes DCV–mediated secretion.
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spelling pubmed-32619152012-01-24 RIC-7 Promotes Neuropeptide Secretion Hao, Yingsong Hu, Zhitao Sieburth, Derek Kaplan, Joshua M. PLoS Genet Research Article Secretion of neurotransmitters and neuropeptides is mediated by exocytosis of distinct secretory organelles, synaptic vesicles (SVs) and dense core vesicles (DCVs) respectively. Relatively little is known about factors that differentially regulate SV and DCV secretion. Here we identify a novel protein RIC-7 that is required for neuropeptide secretion in Caenorhabditis elegans. The RIC-7 protein is expressed in all neurons and is localized to presynaptic terminals. Imaging, electrophysiology, and behavioral analysis of ric-7 mutants indicates that acetylcholine release occurs normally, while neuropeptide release is significantly decreased. These results suggest that RIC-7 promotes DCV–mediated secretion. Public Library of Science 2012-01-19 /pmc/articles/PMC3261915/ /pubmed/22275875 http://dx.doi.org/10.1371/journal.pgen.1002464 Text en Hao et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Hao, Yingsong
Hu, Zhitao
Sieburth, Derek
Kaplan, Joshua M.
RIC-7 Promotes Neuropeptide Secretion
title RIC-7 Promotes Neuropeptide Secretion
title_full RIC-7 Promotes Neuropeptide Secretion
title_fullStr RIC-7 Promotes Neuropeptide Secretion
title_full_unstemmed RIC-7 Promotes Neuropeptide Secretion
title_short RIC-7 Promotes Neuropeptide Secretion
title_sort ric-7 promotes neuropeptide secretion
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3261915/
https://www.ncbi.nlm.nih.gov/pubmed/22275875
http://dx.doi.org/10.1371/journal.pgen.1002464
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AT sieburthderek ric7promotesneuropeptidesecretion
AT kaplanjoshuam ric7promotesneuropeptidesecretion

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