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Progressive Visceral Leishmaniasis Is Driven by Dominant Parasite-induced STAT6 Activation and STAT6-dependent Host Arginase 1 Expression

The clinicopathological features of the hamster model of visceral leishmaniasis (VL) closely mimic active human disease. Studies in humans and hamsters indicate that the inability to control parasite replication in VL could be related to ineffective classical macrophage activation. Therefore, we hyp...

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Detalles Bibliográficos
Autores principales:	Osorio, E. Yaneth, Zhao, Weiguo, Espitia, Claudia, Saldarriaga, Omar, Hawel, Leo, Byus, Craig V., Travi, Bruno L., Melby, Peter C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3261917/ https://www.ncbi.nlm.nih.gov/pubmed/22275864 http://dx.doi.org/10.1371/journal.ppat.1002417

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