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HIV-1 Polymerase Inhibition by Nucleoside Analogs: Cellular- and Kinetic Parameters of Efficacy, Susceptibility and Resistance Selection

Nucleoside analogs (NAs) are used to treat numerous viral infections and cancer. They compete with endogenous nucleotides (dNTP/NTP) for incorporation into nascent DNA/RNA and inhibit replication by preventing subsequent primer extension. To date, an integrated mathematical model that could allow th...

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Detalles Bibliográficos
Autores principales:	von Kleist, Max, Metzner, Philipp, Marquet, Roland, Schütte, Christof
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3261923/ https://www.ncbi.nlm.nih.gov/pubmed/22275860 http://dx.doi.org/10.1371/journal.pcbi.1002359

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