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DNA Methylation and Gene Expression Changes in Monozygotic Twins Discordant for Psoriasis: Identification of Epigenetically Dysregulated Genes

Monozygotic (MZ) twins do not show complete concordance for many complex diseases; for example, discordance rates for autoimmune diseases are 20%–80%. MZ discordance indicates a role for epigenetic or environmental factors in disease. We used MZ twins discordant for psoriasis to search for genome-wi...

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Detalles Bibliográficos
Autores principales:	Gervin, Kristina, Vigeland, Magnus D., Mattingsdal, Morten, Hammerø, Martin, Nygård, Heidi, Olsen, Anne O., Brandt, Ingunn, Harris, Jennifer R., Undlien, Dag E., Lyle, Robert
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262011/ https://www.ncbi.nlm.nih.gov/pubmed/22291603 http://dx.doi.org/10.1371/journal.pgen.1002454

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