Cargando…

Dynamics of HBV cccDNA expression and transcription in different cell growth phase

BACKGROUND: The covalently closed-circular DNA (cccDNA) of hepatitis B virus (HBV) is associated with viral persistence in HBV-infected hepatocytes. However, the regulation of cccDNA and its transcription in the host cells at different growth stages is not well understood. METHODS: We took advantage...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chong, Chin-Liew, Chen, Mong-Liang, Wu, Yi-Chieh, Tsai, Kuen-Nan, Huang, Chien-Chiao, Hu, Cheng-po, Jeng, King-Song, Chou, Yu-Chi, Chang, Chungming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262020/ https://www.ncbi.nlm.nih.gov/pubmed/22208719 http://dx.doi.org/10.1186/1423-0127-18-96

Ejemplares similares

Minicircle HBV cccDNA with a Gaussia luciferase reporter for investigating HBV cccDNA biology and developing cccDNA-targeting drugs
por: Li, Feng, et al.
Publicado: (2016)

The Role of cccDNA in HBV Maintenance
por: Allweiss, Lena, et al.
Publicado: (2017)

HBV cccDNA: The Stumbling Block for Treatment of HBV Infection
por: Liu, Shousheng, et al.
Publicado: (2019)

Mapping the Interactions of HBV cccDNA with Host Factors
por: Mohd-Ismail, Nur K., et al.
Publicado: (2019)

Gene Editing Technologies to Target HBV cccDNA
por: Martinez, Maria Guadalupe, et al.
Publicado: (2022)

HBV cccDNA and Its Potential as a Therapeutic Target
por: Zhu, Anjing, et al.
Publicado: (2019)

Gene Therapy for Chronic HBV—Can We Eliminate cccDNA?
por: Bloom, Kristie, et al.
Publicado: (2018)

Reduced HBV cccDNA and HBsAg in HBV-associated hepatocellular carcinoma tissues
por: Tantiwetrueangdet, Anchalee, et al.
Publicado: (2018)

IL6 Inhibits HBV Transcription by Targeting the Epigenetic Control of the Nuclear cccDNA Minichromosome
por: Palumbo, Gianna Aurora, et al.
Publicado: (2015)

Inhibition of HBV Transcription From cccDNA With Nitazoxanide by Targeting the HBx–DDB1 Interaction
por: Sekiba, Kazuma, et al.
Publicado: (2018)

IFN-α confers epigenetic regulation of HBV cccDNA minichromosome by modulating GCN5-mediated succinylation of histone H3K79 to clear HBV cccDNA
por: Yuan, Ying, et al.
Publicado: (2020)

Cell-based cccDNA reporter assay combined with functional genomics identifies YBX1 as HBV cccDNA host factor and antiviral candidate target
por: Verrier, Eloi R, et al.
Publicado: (2023)

Complete Spectrum of CRISPR/Cas9-induced Mutations on HBV cccDNA
por: Seeger, Christoph, et al.
Publicado: (2016)

Correction: IL6 Inhibits HBV Transcription by Targeting the Epigenetic Control of the Nuclear cccDNA Minichromosome
por: Palumbo, Gianna Aurora, et al.
Publicado: (2015)

Cabozantinib inhibits HBV-RNA transcription by decreasing STAT3 binding to the enhancer region of cccDNA
por: Funato, Kazuyoshi, et al.
Publicado: (2023)

HAT1 signaling confers to assembly and epigenetic regulation of HBV cccDNA minichromosome
por: Yang, Guang, et al.
Publicado: (2019)

Molecular insights into Spindlin1-HBx interplay and its impact on HBV transcription from cccDNA minichromosome
por: Liu, Wei, et al.
Publicado: (2023)

cccDNA Surrogate MC-HBV–Based Screen Identifies Cohesin Complex as a Novel HBV Restriction Factor
por: Wu, Zhuanchang, et al.
Publicado: (2022)

Serum HBV RNA correlated with intrahepatic cccDNA more strongly than other HBV markers during peg-interferon treatment
por: Wang, Xiaomei, et al.
Publicado: (2021)

The recombined cccDNA produced using minicircle technology mimicked HBV genome in structure and function closely
por: Guo, Xiaoyan, et al.
Publicado: (2016)

A dual role for SAMHD1 in regulating HBV cccDNA and RT-dependent particle genesis
por: Wing, Peter AC, et al.
Publicado: (2019)

Baseline value of intrahepatic HBV DNA over cccDNA predicts patient’s response to interferon therapy
por: Mu, Di, et al.
Publicado: (2017)

Droplet digital PCR assay provides intrahepatic HBV cccDNA quantification tool for clinical application
por: Hayashi, Sanae, et al.
Publicado: (2022)

Reduction in Intrahepatic cccDNA and Integration of HBV in Chronic Hepatitis B Patients with a Functional Cure
por: Gan, Weiqiang, et al.
Publicado: (2023)

cccDNA-Targeted Drug Screen Reveals a Class of Antihistamines as Suppressors of HBV Genome Levels
por: Ren, Ee Chee, et al.
Publicado: (2023)

Mechanism of Hepatitis B Virus cccDNA Formation
por: Wei, Lei, et al.
Publicado: (2021)

Quantification of the hepatitis B virus cccDNA: evidence-based guidelines for monitoring the key obstacle of HBV cure
por: Allweiss, Lena, et al.
Publicado: (2023)

Targeting Viral cccDNA for Cure of Chronic Hepatitis B
por: Ligat, Gaëtan, et al.
Publicado: (2020)

Alpha-Interferon Suppresses Hepadnavirus Transcription by Altering Epigenetic Modification of cccDNA Minichromosomes
por: Liu, Fei, et al.
Publicado: (2013)

Evidence for long-term association of virion-delivered HBV core protein with cccDNA independently of viral protein production
por: Lucifora, Julie, et al.
Publicado: (2021)

Estimating hepatitis B virus cccDNA persistence in chronic infection(†)
por: Lythgoe, Katrina A, et al.
Publicado: (2020)

Transforming Growth Factor-β1 Suppresses Hepatitis B Virus Replication by the Reduction of Hepatocyte Nuclear Factor-4α Expression
por: Hong, Ming-Hsiang, et al.
Publicado: (2012)

Yin-Yang 1 and HBx protein activate HBV transcription by mediating the spatial interaction of cccDNA minichromosome with cellular chromosome 19p13.11
por: Shen, Congle, et al.
Publicado: (2020)

De novo synthesis of hepatitis B virus nucleocapsids is dispensable for the maintenance and transcriptional regulation of cccDNA
por: Tu, Thomas, et al.
Publicado: (2020)

HBV core protein allosteric modulators differentially alter cccDNA biosynthesis from de novo infection and intracellular amplification pathways
por: Guo, Fang, et al.
Publicado: (2017)

Suppressing the NHEJ pathway by DNA-PKcs inhibitor NU7026 prevents degradation of HBV cccDNA cleaved by CRISPR/Cas9
por: Kostyushev, Dmitry, et al.
Publicado: (2019)

Flap endonuclease 1 is involved in cccDNA formation in the hepatitis B virus
por: Kitamura, Kouichi, et al.
Publicado: (2018)

cccDNA Maintenance in Chronic Hepatitis B – Targeting the Matrix of Viral Replication
por: Dandri, Maura, et al.
Publicado: (2020)

HBV replication is significantly reduced by IL-6
por: Kuo, Tzer-Min, et al.
Publicado: (2009)

PRKDC promotes hepatitis B virus transcription through enhancing the binding of RNA Pol II to cccDNA
por: Fan, Yao, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_urhjub7mdqs6831q6hugegmdr5