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A protective role for BRCA2 at stalled replication forks

The hereditary breast and ovarian cancer predisposition genes BRCA1 and BRCA2 account for the lion's share of heritable breast cancer risk in the human population. Loss of function of either gene results in defective homologous recombination (HR) and triggers genomic instability, accelerating b...

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Detalles Bibliográficos
Autores principales:	Chandramouly, Gurushankar, Willis, Nicholas A, Scully, Ralph
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Viewpoint
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262192/ https://www.ncbi.nlm.nih.gov/pubmed/21996371 http://dx.doi.org/10.1186/bcr2918

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