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Genomic and phenotypic analysis of BRCA2 mutated breast cancers reveals co-occurring changes linked to progression

BACKGROUND: Inherited mutations in the BRCA2 gene greatly increase the risk of developing breast cancer. Consistent with an important role for BRCA2 in error-free DNA repair, complex genomic changes are frequently observed in tumors derived from BRCA2 mutation carriers. Here, we explore the impact o...

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Detalles Bibliográficos
Autores principales:	Stefansson, Olafur A, Jonasson, Jon G, Olafsdottir, Kristrun, Bjarnason, Hordur, Th Johannsson, Oskar, Bodvarsdottir, Sigridur K, Valgeirsdottir, Sigridur, Eyfjord, Jorunn E
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2011
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262207/ https://www.ncbi.nlm.nih.gov/pubmed/21958427 http://dx.doi.org/10.1186/bcr3020

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