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L-CBM signaling in lymphocyte development and function

The nuclear factor-κB (NF-κB) plays a central role in the activation and survival of lymphocytes. NF-κB, therefore, is pivotal for acquired immunity, but the dysregulation of NF-κB signaling leads to inflammatory diseases and lymphomagenesis. Accumulating evidence has demonstrated that the mucosa-as...

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Detalles Bibliográficos
Autores principales: Hara, Hiromitsu, IIzasa, Eiichi, Nakaya, Mako, Yoshida, Hiroki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2010
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262331/
https://www.ncbi.nlm.nih.gov/pubmed/22282688
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author Hara, Hiromitsu
IIzasa, Eiichi
Nakaya, Mako
Yoshida, Hiroki
author_facet Hara, Hiromitsu
IIzasa, Eiichi
Nakaya, Mako
Yoshida, Hiroki
author_sort Hara, Hiromitsu
collection PubMed
description The nuclear factor-κB (NF-κB) plays a central role in the activation and survival of lymphocytes. NF-κB, therefore, is pivotal for acquired immunity, but the dysregulation of NF-κB signaling leads to inflammatory diseases and lymphomagenesis. Accumulating evidence has demonstrated that the mucosa-associated lymphoid tissue (MALT) lymphoma-related molecules, B-cell lymphoma 10 (BCL10) and MALT-lymphoma-translocation gene1 (MALT1), are essential signaling components for NF-κB and mitogen-activated protein kinase (MAPK) activation, mediated by the immunoreceptor tyrosine-based activation motif (ITAM)-coupled receptors involved in both innate and adaptive immunity. CARMA1 (also referred to as CARD11 and Bimp3) is a crucial regulator for ITAM-mediated signaling as it forms a complex with BCL10-MALT1 in lymphoid lineage cells such as T, B, natural killer (NK), and natural killer T (NKT) cells, known as the lymphoid CARMA1-BCL10-MALT1 (L-CBM) complex. In this review, recent understanding of the molecular and biological functions and the signal regulation mechanisms of the L-CBM complex are described and its role in disease development and potential as a therapeutic target is further discussed.
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spelling pubmed-32623312012-01-26 L-CBM signaling in lymphocyte development and function Hara, Hiromitsu IIzasa, Eiichi Nakaya, Mako Yoshida, Hiroki J Blood Med Review The nuclear factor-κB (NF-κB) plays a central role in the activation and survival of lymphocytes. NF-κB, therefore, is pivotal for acquired immunity, but the dysregulation of NF-κB signaling leads to inflammatory diseases and lymphomagenesis. Accumulating evidence has demonstrated that the mucosa-associated lymphoid tissue (MALT) lymphoma-related molecules, B-cell lymphoma 10 (BCL10) and MALT-lymphoma-translocation gene1 (MALT1), are essential signaling components for NF-κB and mitogen-activated protein kinase (MAPK) activation, mediated by the immunoreceptor tyrosine-based activation motif (ITAM)-coupled receptors involved in both innate and adaptive immunity. CARMA1 (also referred to as CARD11 and Bimp3) is a crucial regulator for ITAM-mediated signaling as it forms a complex with BCL10-MALT1 in lymphoid lineage cells such as T, B, natural killer (NK), and natural killer T (NKT) cells, known as the lymphoid CARMA1-BCL10-MALT1 (L-CBM) complex. In this review, recent understanding of the molecular and biological functions and the signal regulation mechanisms of the L-CBM complex are described and its role in disease development and potential as a therapeutic target is further discussed. Dove Medical Press 2010-06-04 /pmc/articles/PMC3262331/ /pubmed/22282688 Text en © 2010 Hara et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.
spellingShingle Review
Hara, Hiromitsu
IIzasa, Eiichi
Nakaya, Mako
Yoshida, Hiroki
L-CBM signaling in lymphocyte development and function
title L-CBM signaling in lymphocyte development and function
title_full L-CBM signaling in lymphocyte development and function
title_fullStr L-CBM signaling in lymphocyte development and function
title_full_unstemmed L-CBM signaling in lymphocyte development and function
title_short L-CBM signaling in lymphocyte development and function
title_sort l-cbm signaling in lymphocyte development and function
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262331/
https://www.ncbi.nlm.nih.gov/pubmed/22282688
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