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L-CBM signaling in lymphocyte development and function
The nuclear factor-κB (NF-κB) plays a central role in the activation and survival of lymphocytes. NF-κB, therefore, is pivotal for acquired immunity, but the dysregulation of NF-κB signaling leads to inflammatory diseases and lymphomagenesis. Accumulating evidence has demonstrated that the mucosa-as...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2010
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262331/ https://www.ncbi.nlm.nih.gov/pubmed/22282688 |
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author | Hara, Hiromitsu IIzasa, Eiichi Nakaya, Mako Yoshida, Hiroki |
author_facet | Hara, Hiromitsu IIzasa, Eiichi Nakaya, Mako Yoshida, Hiroki |
author_sort | Hara, Hiromitsu |
collection | PubMed |
description | The nuclear factor-κB (NF-κB) plays a central role in the activation and survival of lymphocytes. NF-κB, therefore, is pivotal for acquired immunity, but the dysregulation of NF-κB signaling leads to inflammatory diseases and lymphomagenesis. Accumulating evidence has demonstrated that the mucosa-associated lymphoid tissue (MALT) lymphoma-related molecules, B-cell lymphoma 10 (BCL10) and MALT-lymphoma-translocation gene1 (MALT1), are essential signaling components for NF-κB and mitogen-activated protein kinase (MAPK) activation, mediated by the immunoreceptor tyrosine-based activation motif (ITAM)-coupled receptors involved in both innate and adaptive immunity. CARMA1 (also referred to as CARD11 and Bimp3) is a crucial regulator for ITAM-mediated signaling as it forms a complex with BCL10-MALT1 in lymphoid lineage cells such as T, B, natural killer (NK), and natural killer T (NKT) cells, known as the lymphoid CARMA1-BCL10-MALT1 (L-CBM) complex. In this review, recent understanding of the molecular and biological functions and the signal regulation mechanisms of the L-CBM complex are described and its role in disease development and potential as a therapeutic target is further discussed. |
format | Online Article Text |
id | pubmed-3262331 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2010 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-32623312012-01-26 L-CBM signaling in lymphocyte development and function Hara, Hiromitsu IIzasa, Eiichi Nakaya, Mako Yoshida, Hiroki J Blood Med Review The nuclear factor-κB (NF-κB) plays a central role in the activation and survival of lymphocytes. NF-κB, therefore, is pivotal for acquired immunity, but the dysregulation of NF-κB signaling leads to inflammatory diseases and lymphomagenesis. Accumulating evidence has demonstrated that the mucosa-associated lymphoid tissue (MALT) lymphoma-related molecules, B-cell lymphoma 10 (BCL10) and MALT-lymphoma-translocation gene1 (MALT1), are essential signaling components for NF-κB and mitogen-activated protein kinase (MAPK) activation, mediated by the immunoreceptor tyrosine-based activation motif (ITAM)-coupled receptors involved in both innate and adaptive immunity. CARMA1 (also referred to as CARD11 and Bimp3) is a crucial regulator for ITAM-mediated signaling as it forms a complex with BCL10-MALT1 in lymphoid lineage cells such as T, B, natural killer (NK), and natural killer T (NKT) cells, known as the lymphoid CARMA1-BCL10-MALT1 (L-CBM) complex. In this review, recent understanding of the molecular and biological functions and the signal regulation mechanisms of the L-CBM complex are described and its role in disease development and potential as a therapeutic target is further discussed. Dove Medical Press 2010-06-04 /pmc/articles/PMC3262331/ /pubmed/22282688 Text en © 2010 Hara et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited. |
spellingShingle | Review Hara, Hiromitsu IIzasa, Eiichi Nakaya, Mako Yoshida, Hiroki L-CBM signaling in lymphocyte development and function |
title | L-CBM signaling in lymphocyte development and function |
title_full | L-CBM signaling in lymphocyte development and function |
title_fullStr | L-CBM signaling in lymphocyte development and function |
title_full_unstemmed | L-CBM signaling in lymphocyte development and function |
title_short | L-CBM signaling in lymphocyte development and function |
title_sort | l-cbm signaling in lymphocyte development and function |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262331/ https://www.ncbi.nlm.nih.gov/pubmed/22282688 |
work_keys_str_mv | AT harahiromitsu lcbmsignalinginlymphocytedevelopmentandfunction AT iizasaeiichi lcbmsignalinginlymphocytedevelopmentandfunction AT nakayamako lcbmsignalinginlymphocytedevelopmentandfunction AT yoshidahiroki lcbmsignalinginlymphocytedevelopmentandfunction |