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Subclinical leukopenia in a cross section of Nigerian blood donors

BACKGROUND: Most studies on blood donors are centered on the selective evaluation of red blood cell parameters with little or no regard to white blood cells and platelets. METHODS: One hundred and twelve male blood donors comprising 43 first-time and 69 regular blood donors, drawn from a tertiary he...

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Autores principales: Jeremiah, Zaccheaus A, Umoh, Ruth E, Adias, Teddy C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262351/
https://www.ncbi.nlm.nih.gov/pubmed/22287866
http://dx.doi.org/10.2147/JBM.S16214
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author Jeremiah, Zaccheaus A
Umoh, Ruth E
Adias, Teddy C
author_facet Jeremiah, Zaccheaus A
Umoh, Ruth E
Adias, Teddy C
author_sort Jeremiah, Zaccheaus A
collection PubMed
description BACKGROUND: Most studies on blood donors are centered on the selective evaluation of red blood cell parameters with little or no regard to white blood cells and platelets. METHODS: One hundred and twelve male blood donors comprising 43 first-time and 69 regular blood donors, drawn from a tertiary health facility in the Niger Delta of Nigeria, participated in the study. Their hematological parameters were assessed using a 3-part differential autohematology analyzer (PCE-210 N). RESULTS: Of the blood donors, 18.8% were found to be anemic (packed cell volume [PCV] <33%) while 12.5% were leukopenic (white blood cell [WBC] count <2.0 × 10(9)/L). The leukopenia observed in this study was largely due to the significant reductions in both the absolute lymphocyte (P = 0.019), percent lymphocyte (P = 0.016), and percent monocyte count (P = 0.008). Anemia was obviously due to the reduction in the red blood cell (RBC) count, PCV, hemoglobin (Hb), mean cell Hb (MCH), and red cell distribution width (RDW) values. Significant positive correlations were found between PCV and total WBC count (r = 0.309; P < 0.01) while a negative correlation was found between PCV and absolute lymphocyte counts (r = −0.191; P < 0.005) and RDW (r = −0.219; P < 0.05). Comparison of the mean values of the first-time versus regular blood donor parameters revealed that six parameters were significantly reduced in the regular blood donors (PCV, absolute WBC count, percent monocytes, RBC count, Hb, PCV). The reference ranges of hematological parameters for Port Harcourt donors are also presented in this study. No thrombocytopenia was observed. CONCLUSION: Regular blood donation not only affects red cell parameters but also those of white cells. Subclinical leukopenia is present among regular blood donors in this locality. First-time blood donors would be most preferable when the concentrated white blood cell component of blood needs to be prepared.
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spelling pubmed-32623512012-01-27 Subclinical leukopenia in a cross section of Nigerian blood donors Jeremiah, Zaccheaus A Umoh, Ruth E Adias, Teddy C J Blood Med Original Research BACKGROUND: Most studies on blood donors are centered on the selective evaluation of red blood cell parameters with little or no regard to white blood cells and platelets. METHODS: One hundred and twelve male blood donors comprising 43 first-time and 69 regular blood donors, drawn from a tertiary health facility in the Niger Delta of Nigeria, participated in the study. Their hematological parameters were assessed using a 3-part differential autohematology analyzer (PCE-210 N). RESULTS: Of the blood donors, 18.8% were found to be anemic (packed cell volume [PCV] <33%) while 12.5% were leukopenic (white blood cell [WBC] count <2.0 × 10(9)/L). The leukopenia observed in this study was largely due to the significant reductions in both the absolute lymphocyte (P = 0.019), percent lymphocyte (P = 0.016), and percent monocyte count (P = 0.008). Anemia was obviously due to the reduction in the red blood cell (RBC) count, PCV, hemoglobin (Hb), mean cell Hb (MCH), and red cell distribution width (RDW) values. Significant positive correlations were found between PCV and total WBC count (r = 0.309; P < 0.01) while a negative correlation was found between PCV and absolute lymphocyte counts (r = −0.191; P < 0.005) and RDW (r = −0.219; P < 0.05). Comparison of the mean values of the first-time versus regular blood donor parameters revealed that six parameters were significantly reduced in the regular blood donors (PCV, absolute WBC count, percent monocytes, RBC count, Hb, PCV). The reference ranges of hematological parameters for Port Harcourt donors are also presented in this study. No thrombocytopenia was observed. CONCLUSION: Regular blood donation not only affects red cell parameters but also those of white cells. Subclinical leukopenia is present among regular blood donors in this locality. First-time blood donors would be most preferable when the concentrated white blood cell component of blood needs to be prepared. Dove Medical Press 2011-05-11 /pmc/articles/PMC3262351/ /pubmed/22287866 http://dx.doi.org/10.2147/JBM.S16214 Text en © 2011 Jeremiah et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.
spellingShingle Original Research
Jeremiah, Zaccheaus A
Umoh, Ruth E
Adias, Teddy C
Subclinical leukopenia in a cross section of Nigerian blood donors
title Subclinical leukopenia in a cross section of Nigerian blood donors
title_full Subclinical leukopenia in a cross section of Nigerian blood donors
title_fullStr Subclinical leukopenia in a cross section of Nigerian blood donors
title_full_unstemmed Subclinical leukopenia in a cross section of Nigerian blood donors
title_short Subclinical leukopenia in a cross section of Nigerian blood donors
title_sort subclinical leukopenia in a cross section of nigerian blood donors
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262351/
https://www.ncbi.nlm.nih.gov/pubmed/22287866
http://dx.doi.org/10.2147/JBM.S16214
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