Cargando…

Neuronal potassium channel openers in the management of epilepsy: role and potential of retigabine

Despite the availability of over 20 antiepileptic drugs, about 30% of epileptic patients do not achieve seizure control. Thus, identification of additional molecules targeting novel molecular mechanisms is a primary effort in today’s antiepileptic drug research. This paper reviews the pharmacologica...

Descripción completa

Detalles Bibliográficos
Autores principales:	Barrese, Vincenzo, Miceli, Francesco, Soldovieri, Maria Virginia, Ambrosino, Paolo, Iannotti, Fabio Arturo, Cilio, Maria Roberta, Taglialatela, Maurizio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2010
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262367/ https://www.ncbi.nlm.nih.gov/pubmed/22291509 http://dx.doi.org/10.2147/CPAA.S15369

Ejemplares similares

The Voltage-Sensing Domain of K(v)7.2 Channels as a Molecular Target for Epilepsy-Causing Mutations and Anticonvulsants
por: Miceli, Francesco, et al.
Publicado: (2011)

Specification of skeletal muscle differentiation by repressor element-1 silencing transcription factor (REST)-regulated K(v)7.4 potassium channels
por: Iannotti, Fabio Arturo, et al.
Publicado: (2013)

Activation of Kv7 Potassium Channels Inhibits Intracellular Ca(2+) Increases Triggered By TRPV1-Mediated Pain-Inducing Stimuli in F11 Immortalized Sensory Neurons
por: Ambrosino, Paolo, et al.
Publicado: (2019)

Molecular pathophysiology and pharmacology of the voltage-sensing module of neuronal ion channels
por: Miceli, Francesco, et al.
Publicado: (2015)

A Novel Kv7.3 Variant in the Voltage-Sensing S(4) Segment in a Family With Benign Neonatal Epilepsy: Functional Characterization and in vitro Rescue by β-Hydroxybutyrate
por: Miceli, Francesco, et al.
Publicado: (2020)

Beyond Retigabine: Design, Synthesis, and Pharmacological Characterization of a Potent and Chemically Stable Neuronal Kv7 Channel Activator with Anticonvulsant Activity
por: Musella, Simona, et al.
Publicado: (2022)

Early-onset epileptic encephalopathy caused by a reduced sensitivity of Kv7.2 potassium channels to phosphatidylinositol 4,5-bisphosphate
por: Soldovieri, Maria Virginia, et al.
Publicado: (2016)

Gain of function due to increased opening probability by two KCNQ5 pore variants causing developmental and epileptic encephalopathy
por: Nappi, Mario, et al.
Publicado: (2022)

Functional Characterization of Two Variants at the Intron 6—Exon 7 Boundary of the KCNQ2 Potassium Channel Gene Causing Distinct Epileptic Phenotypes
por: Mosca, Ilaria, et al.
Publicado: (2022)

Electro-mechanical coupling of KCNQ channels is a target of epilepsy-associated mutations and retigabine
por: Yang, Nien-Du, et al.
Publicado: (2022)

Distinct epilepsy phenotypes and response to drugs in KCNA1 gain‐ and loss‐of function variants
por: Miceli, Francesco, et al.
Publicado: (2021)

Retigabine holds K(V)7 channels open and stabilizes the resting potential
por: Corbin-Leftwich, Aaron, et al.
Publicado: (2016)

Differential Regulation of PI(4,5)P(2) Sensitivity of Kv7.2 and Kv7.3 Channels by Calmodulin
por: Gomis-Perez, Carolina, et al.
Publicado: (2017)

Clinical utility, safety, and tolerability of ezogabine (retigabine) in the treatment of epilepsy
por: Ciliberto, Michael A, et al.
Publicado: (2012)

New advances in beta-blocker therapy in heart failure
por: Barrese, Vincenzo, et al.
Publicado: (2013)

A novel homozygous KCNQ3 loss‐of‐function variant causes non‐syndromic intellectual disability and neonatal‐onset pharmacodependent epilepsy
por: Lauritano, Anna, et al.
Publicado: (2019)

Epileptic Encephalopathy In A Patient With A Novel Variant In The Kv7.2 S(2) Transmembrane Segment: Clinical, Genetic, and Functional Features
por: Soldovieri, Maria Virginia, et al.
Publicado: (2019)

Molecular Insights Into Binding and Activation of the Human KCNQ2 Channel by Retigabine
por: Garofalo, Barbara, et al.
Publicado: (2022)

The Effects of the KCNQ Openers Retigabine and Flupirtine on Myotonia in Mammalian Skeletal Muscle Induced by a Chloride Channel Blocker
por: Su, Tzu-Rong, et al.
Publicado: (2012)

K(+) channelepsy: progress in the neurobiology of potassium channels and epilepsy
por: D'Adamo, Maria Cristina, et al.
Publicado: (2013)

Editorial: Kv7 Channels: Structure, Physiology, and Pharmacology
por: Jepps, Thomas A., et al.
Publicado: (2021)

Erratum: K(+) channelepsy: progress in the neurobiology of potassium channels and epilepsy
por: D'Adamo, Maria C., et al.
Publicado: (2014)

The anticonvulsant retigabine suppresses neuronal K(V)2-mediated currents
por: Stas, Jeroen I., et al.
Publicado: (2016)

One drug-sensitive subunit is sufficient for a near-maximal retigabine effect in KCNQ channels
por: Yau, Michael C., et al.
Publicado: (2018)

Efficacy of Retigabine on Acute Limbic Seizures in Adult Rats
por: Friedman, LK, et al.
Publicado: (2015)

European Survey of Prescriber Understanding of Risks Associated with Retigabine
por: Ishihara, Lianna, et al.
Publicado: (2015)

Survey of Physicians’ Understanding of Specific Risks Associated with Retigabine
por: Daniluk, Jerzy, et al.
Publicado: (2016)

Beneficial effect of retigabine on memory in rats receiving ethanol
por: Zwierzyńska, Ewa, et al.
Publicado: (2020)

Combining endocannabinoids with retigabine for enhanced M-channel effect and improved K(V)7 subtype selectivity
por: Larsson, Johan E., et al.
Publicado: (2020)

Clinical utility of adjunctive retigabine in partial onset seizures in adults
por: Rejdak, Konrad, et al.
Publicado: (2012)

Efficacy of Retigabine in Adjunctive Treatment of Partial Onset Seizures in Adults
por: Splinter, Michele Y.
Publicado: (2013)

K(V)7 channels regulate muscle tone and nonadrenergic noncholinergic relaxation of the rat gastric fundus
por: Ipavec, V., et al.
Publicado: (2011)

The Kv7 channel activator, retigabine, induces vasorelaxation via an endothelial-independent pathway in male mouse aorta
por: Namgoong, Hyun, et al.
Publicado: (2018)

Orofacial neuropathic pain induced by oxaliplatin: Downregulation of KCNQ2 channels in V2 trigeminal ganglion neurons and treatment by the KCNQ2 channel potentiator retigabine
por: Ling, Jennifer, et al.
Publicado: (2017)

Acute retigabine‐induced effects on myelinated motor axons in amyotrophic lateral sclerosis
por: Sleutjes, Boudewijn T. H. M., et al.
Publicado: (2022)

The anticonvulsant retigabine is a subtype selective modulator of GABA (A) receptors
por: Treven, Marco, et al.
Publicado: (2015)

Retigabine suppresses loss of force in mouse models of hypokalaemic periodic paralysis
por: Quiñonez, Marbella, et al.
Publicado: (2023)

Epilepsy Gene Therapy Using an Engineered Potassium Channel
por: Snowball, Albert, et al.
Publicado: (2019)

Editorial: “Small molecules targeting transmembrane receptors and ion channels in drug discovery”
por: Vitale, Rosa Maria, et al.
Publicado: (2023)

Activation of voltage-gated KCNQ/Kv7 channels by anticonvulsant retigabine attenuates mechanical allodynia of inflammatory temporomandibular joint in rats
por: Xu, Wen, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_5pnfsemd16uglnccs65h2kpk10