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In vitro cytotoxicity of combinations of dichloroacetate with anticancer platinum compounds

PURPOSE: Dichloroacetate (DCA) inhibits pyruvate dehydrogenase kinase (PDK), and thus promotes glucose oxidation over glycolysis and induces apoptotic death of tumor cells. The present study investigated the potential of DCA to increase the antitumor effects of platinum- based compounds against a pa...

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Detalles Bibliográficos
Autores principales:	Olszewski, Ulrike, Poulsen, Thomas Tuxen, Ulsperger, Ernst, Poulsen, Hans Skovgard, Geissler, Klaus, Hamilton, Gerhard
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2010
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262384/ https://www.ncbi.nlm.nih.gov/pubmed/22291503 http://dx.doi.org/10.2147/CPAA.S11795

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