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Nevus Senescence
Melanomas and nevi share many of the same growth-promoting mutations. However, melanomas grow relentlessly while benign nevi eventually undergo growth arrest and stabilize. The difference in their long-term growth potential may be attributed to activation of cellular senescence pathways. The primary...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Scholarly Research Network
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262546/ https://www.ncbi.nlm.nih.gov/pubmed/22363855 http://dx.doi.org/10.5402/2011/642157 |
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author | Ross, Andrew L. Sanchez, Margaret I. Grichnik, James M. |
author_facet | Ross, Andrew L. Sanchez, Margaret I. Grichnik, James M. |
author_sort | Ross, Andrew L. |
collection | PubMed |
description | Melanomas and nevi share many of the same growth-promoting mutations. However, melanomas grow relentlessly while benign nevi eventually undergo growth arrest and stabilize. The difference in their long-term growth potential may be attributed to activation of cellular senescence pathways. The primary mediator of senescence in nevi appears to be p16. Redundant, secondary senescence systems are also present and include the p14-p53-p21 pathway, the IGFBP7 pathway, the FBXO31 pathway, and the PI3K mediated stress induced endoplasmic reticulum unfolded protein response. It is evident that these senescence pathways result in an irreversible arrest in most instances; however, they can clearly be overcome in melanoma. Circumvention of these pathways is most frequently associated with gene deletion or transcriptional repression. Reactivation of senescence mechanisms could serve to inhibit melanoma tumor progression. |
format | Online Article Text |
id | pubmed-3262546 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | International Scholarly Research Network |
record_format | MEDLINE/PubMed |
spelling | pubmed-32625462012-02-23 Nevus Senescence Ross, Andrew L. Sanchez, Margaret I. Grichnik, James M. ISRN Dermatol Research Article Melanomas and nevi share many of the same growth-promoting mutations. However, melanomas grow relentlessly while benign nevi eventually undergo growth arrest and stabilize. The difference in their long-term growth potential may be attributed to activation of cellular senescence pathways. The primary mediator of senescence in nevi appears to be p16. Redundant, secondary senescence systems are also present and include the p14-p53-p21 pathway, the IGFBP7 pathway, the FBXO31 pathway, and the PI3K mediated stress induced endoplasmic reticulum unfolded protein response. It is evident that these senescence pathways result in an irreversible arrest in most instances; however, they can clearly be overcome in melanoma. Circumvention of these pathways is most frequently associated with gene deletion or transcriptional repression. Reactivation of senescence mechanisms could serve to inhibit melanoma tumor progression. International Scholarly Research Network 2011 2011-06-22 /pmc/articles/PMC3262546/ /pubmed/22363855 http://dx.doi.org/10.5402/2011/642157 Text en Copyright © 2011 Andrew L. Ross et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Ross, Andrew L. Sanchez, Margaret I. Grichnik, James M. Nevus Senescence |
title | Nevus Senescence |
title_full | Nevus Senescence |
title_fullStr | Nevus Senescence |
title_full_unstemmed | Nevus Senescence |
title_short | Nevus Senescence |
title_sort | nevus senescence |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262546/ https://www.ncbi.nlm.nih.gov/pubmed/22363855 http://dx.doi.org/10.5402/2011/642157 |
work_keys_str_mv | AT rossandrewl nevussenescence AT sanchezmargareti nevussenescence AT grichnikjamesm nevussenescence |