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A Role for Estrogen Receptor Phosphorylation in the Resistance to Tamoxifen
About two thirds of all human breast cancer cases are estrogen receptor positive. The drug of first choice for these patients is tamoxifen. However, about half of the recurrences after removal of the primary tumor are or become resistant to this drug. While many mechanisms have been identified for t...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE-Hindawi Access to Research
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262574/ https://www.ncbi.nlm.nih.gov/pubmed/22295213 http://dx.doi.org/10.4061/2011/232435 |
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author | de Leeuw, Renée Neefjes, Jacques Michalides, Rob |
author_facet | de Leeuw, Renée Neefjes, Jacques Michalides, Rob |
author_sort | de Leeuw, Renée |
collection | PubMed |
description | About two thirds of all human breast cancer cases are estrogen receptor positive. The drug of first choice for these patients is tamoxifen. However, about half of the recurrences after removal of the primary tumor are or become resistant to this drug. While many mechanisms have been identified for tamoxifen resistance in the lab, at present only a few have been translated to the clinic. This paper highlights the role in tamoxifen resistance of phosphorylation by different kinases on different sites of the estrogen receptor. We will discuss the molecular pathways and kinases that are involved in phosphorylation of ERα and how these affect tamoxifen resistance. Finally, we will elaborate on the clinical translation of these observations and the possibility to predict tamoxifen responses in patient tumor samples before treatment onset. The findings made originally on the bench may translate into a better and personalized treatment of breast cancer patients using an old and safe anticancer drug: tamoxifen. |
format | Online Article Text |
id | pubmed-3262574 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | SAGE-Hindawi Access to Research |
record_format | MEDLINE/PubMed |
spelling | pubmed-32625742012-01-31 A Role for Estrogen Receptor Phosphorylation in the Resistance to Tamoxifen de Leeuw, Renée Neefjes, Jacques Michalides, Rob Int J Breast Cancer Review Article About two thirds of all human breast cancer cases are estrogen receptor positive. The drug of first choice for these patients is tamoxifen. However, about half of the recurrences after removal of the primary tumor are or become resistant to this drug. While many mechanisms have been identified for tamoxifen resistance in the lab, at present only a few have been translated to the clinic. This paper highlights the role in tamoxifen resistance of phosphorylation by different kinases on different sites of the estrogen receptor. We will discuss the molecular pathways and kinases that are involved in phosphorylation of ERα and how these affect tamoxifen resistance. Finally, we will elaborate on the clinical translation of these observations and the possibility to predict tamoxifen responses in patient tumor samples before treatment onset. The findings made originally on the bench may translate into a better and personalized treatment of breast cancer patients using an old and safe anticancer drug: tamoxifen. SAGE-Hindawi Access to Research 2011 2011-07-12 /pmc/articles/PMC3262574/ /pubmed/22295213 http://dx.doi.org/10.4061/2011/232435 Text en Copyright © 2011 Renée de Leeuw et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article de Leeuw, Renée Neefjes, Jacques Michalides, Rob A Role for Estrogen Receptor Phosphorylation in the Resistance to Tamoxifen |
title | A Role for Estrogen Receptor Phosphorylation in the Resistance to Tamoxifen |
title_full | A Role for Estrogen Receptor Phosphorylation in the Resistance to Tamoxifen |
title_fullStr | A Role for Estrogen Receptor Phosphorylation in the Resistance to Tamoxifen |
title_full_unstemmed | A Role for Estrogen Receptor Phosphorylation in the Resistance to Tamoxifen |
title_short | A Role for Estrogen Receptor Phosphorylation in the Resistance to Tamoxifen |
title_sort | role for estrogen receptor phosphorylation in the resistance to tamoxifen |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262574/ https://www.ncbi.nlm.nih.gov/pubmed/22295213 http://dx.doi.org/10.4061/2011/232435 |
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