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Endocrine Alterations Are the Main Determinants of Cardiac Remodelling in Restrictive Anorexia Nervosa

Objective. Anorexia nervosa is a condition of reduced hemodynamic load, characterized by varying degrees of cardiac remodelling, only in part related to reduced body mass; the mechanism for such variability, as well as its clinical significance, remains unknown. Aim of the study was to assess the po...

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Autores principales: Carlomagno, Guido, Mercurio, Valentina, Ruvolo, Antonio, Senatore, Ignazio, Halinskaya, Irina, Fazio, Valeria, Affuso, Flora, Fazio, Serafino
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scholarly Research Network 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262625/
https://www.ncbi.nlm.nih.gov/pubmed/22363867
http://dx.doi.org/10.5402/2011/171460
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author Carlomagno, Guido
Mercurio, Valentina
Ruvolo, Antonio
Senatore, Ignazio
Halinskaya, Irina
Fazio, Valeria
Affuso, Flora
Fazio, Serafino
author_facet Carlomagno, Guido
Mercurio, Valentina
Ruvolo, Antonio
Senatore, Ignazio
Halinskaya, Irina
Fazio, Valeria
Affuso, Flora
Fazio, Serafino
author_sort Carlomagno, Guido
collection PubMed
description Objective. Anorexia nervosa is a condition of reduced hemodynamic load, characterized by varying degrees of cardiac remodelling, only in part related to reduced body mass; the mechanism for such variability, as well as its clinical significance, remains unknown. Aim of the study was to assess the possible influence of a great number of clinical, biochemical, and endocrine factors on cardiovascular parameters in restrictive anorexia nervosa. Method. Twenty-five female patients hospitalized for restrictive anorexia nervosa underwent extensive cardiovascular, clinical, and biochemical evaluation. Results. Height-adjusted and cardiac workload-matched left ventricular mass was significantly related to several endocrine parameters, blood pressure, and vasoreactivity. On multivariate analysis, IGF/GH ratio and systolic blood pressure were the only independent predictors of height-adjusted ventricular mass (adj-R (2) = 0.585; P = 0.001); when matching for cardiac workload, left ventricular mass was independently predicted only by GH and FT3 levels. All effects were independent of patient's weight and BMI. Conclusions. Indices of endocrine impairment seem to be the most relevant determinants of left ventricular hypotrophy in anorectic patients, apparently independent of reduced hemodynamic load and BMI. In particular, IGF/GH ratio and FT3 seem to particularly affect left ventricular mass in this population.
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spelling pubmed-32626252012-02-23 Endocrine Alterations Are the Main Determinants of Cardiac Remodelling in Restrictive Anorexia Nervosa Carlomagno, Guido Mercurio, Valentina Ruvolo, Antonio Senatore, Ignazio Halinskaya, Irina Fazio, Valeria Affuso, Flora Fazio, Serafino ISRN Endocrinol Research Article Objective. Anorexia nervosa is a condition of reduced hemodynamic load, characterized by varying degrees of cardiac remodelling, only in part related to reduced body mass; the mechanism for such variability, as well as its clinical significance, remains unknown. Aim of the study was to assess the possible influence of a great number of clinical, biochemical, and endocrine factors on cardiovascular parameters in restrictive anorexia nervosa. Method. Twenty-five female patients hospitalized for restrictive anorexia nervosa underwent extensive cardiovascular, clinical, and biochemical evaluation. Results. Height-adjusted and cardiac workload-matched left ventricular mass was significantly related to several endocrine parameters, blood pressure, and vasoreactivity. On multivariate analysis, IGF/GH ratio and systolic blood pressure were the only independent predictors of height-adjusted ventricular mass (adj-R (2) = 0.585; P = 0.001); when matching for cardiac workload, left ventricular mass was independently predicted only by GH and FT3 levels. All effects were independent of patient's weight and BMI. Conclusions. Indices of endocrine impairment seem to be the most relevant determinants of left ventricular hypotrophy in anorectic patients, apparently independent of reduced hemodynamic load and BMI. In particular, IGF/GH ratio and FT3 seem to particularly affect left ventricular mass in this population. International Scholarly Research Network 2011 2011-07-02 /pmc/articles/PMC3262625/ /pubmed/22363867 http://dx.doi.org/10.5402/2011/171460 Text en Copyright © 2011 Guido Carlomagno et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Carlomagno, Guido
Mercurio, Valentina
Ruvolo, Antonio
Senatore, Ignazio
Halinskaya, Irina
Fazio, Valeria
Affuso, Flora
Fazio, Serafino
Endocrine Alterations Are the Main Determinants of Cardiac Remodelling in Restrictive Anorexia Nervosa
title Endocrine Alterations Are the Main Determinants of Cardiac Remodelling in Restrictive Anorexia Nervosa
title_full Endocrine Alterations Are the Main Determinants of Cardiac Remodelling in Restrictive Anorexia Nervosa
title_fullStr Endocrine Alterations Are the Main Determinants of Cardiac Remodelling in Restrictive Anorexia Nervosa
title_full_unstemmed Endocrine Alterations Are the Main Determinants of Cardiac Remodelling in Restrictive Anorexia Nervosa
title_short Endocrine Alterations Are the Main Determinants of Cardiac Remodelling in Restrictive Anorexia Nervosa
title_sort endocrine alterations are the main determinants of cardiac remodelling in restrictive anorexia nervosa
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262625/
https://www.ncbi.nlm.nih.gov/pubmed/22363867
http://dx.doi.org/10.5402/2011/171460
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