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Gray matter imaging in multiple sclerosis: what have we learned?
At the early onset of the 20(th )century, several studies already reported that the gray matter was implicated in the histopathology of multiple sclerosis (MS). However, as white matter pathology long received predominant attention in this disease, and histological staining techniques for detecting...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262750/ https://www.ncbi.nlm.nih.gov/pubmed/22152037 http://dx.doi.org/10.1186/1471-2377-11-153 |
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author | Hulst, Hanneke E Geurts, Jeroen JG |
author_facet | Hulst, Hanneke E Geurts, Jeroen JG |
author_sort | Hulst, Hanneke E |
collection | PubMed |
description | At the early onset of the 20(th )century, several studies already reported that the gray matter was implicated in the histopathology of multiple sclerosis (MS). However, as white matter pathology long received predominant attention in this disease, and histological staining techniques for detecting myelin in the gray matter were suboptimal, it was not until the beginning of the 21(st )century that the true extent and importance of gray matter pathology in MS was finally recognized. Gray matter damage was shown to be frequent and extensive, and more pronounced in the progressive disease phases. Several studies subsequently demonstrated that the histopathology of gray matter lesions differs from that of white matter lesions. Unfortunately, imaging of pathology in gray matter structures proved to be difficult, especially when using conventional magnetic resonance imaging (MRI) techniques. However, with the recent introduction of several more advanced MRI techniques, the detection of cortical and subcortical damage in MS has considerably improved. This has important consequences for studying the clinical correlates of gray matter damage. In this review, we provide an overview of what has been learned about imaging of gray matter damage in MS, and offer a brief perspective with regards to future developments in this field. |
format | Online Article Text |
id | pubmed-3262750 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-32627502012-01-21 Gray matter imaging in multiple sclerosis: what have we learned? Hulst, Hanneke E Geurts, Jeroen JG BMC Neurol Review At the early onset of the 20(th )century, several studies already reported that the gray matter was implicated in the histopathology of multiple sclerosis (MS). However, as white matter pathology long received predominant attention in this disease, and histological staining techniques for detecting myelin in the gray matter were suboptimal, it was not until the beginning of the 21(st )century that the true extent and importance of gray matter pathology in MS was finally recognized. Gray matter damage was shown to be frequent and extensive, and more pronounced in the progressive disease phases. Several studies subsequently demonstrated that the histopathology of gray matter lesions differs from that of white matter lesions. Unfortunately, imaging of pathology in gray matter structures proved to be difficult, especially when using conventional magnetic resonance imaging (MRI) techniques. However, with the recent introduction of several more advanced MRI techniques, the detection of cortical and subcortical damage in MS has considerably improved. This has important consequences for studying the clinical correlates of gray matter damage. In this review, we provide an overview of what has been learned about imaging of gray matter damage in MS, and offer a brief perspective with regards to future developments in this field. BioMed Central 2011-12-12 /pmc/articles/PMC3262750/ /pubmed/22152037 http://dx.doi.org/10.1186/1471-2377-11-153 Text en Copyright ©2011 Hulst and Geurts; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Hulst, Hanneke E Geurts, Jeroen JG Gray matter imaging in multiple sclerosis: what have we learned? |
title | Gray matter imaging in multiple sclerosis: what have we learned? |
title_full | Gray matter imaging in multiple sclerosis: what have we learned? |
title_fullStr | Gray matter imaging in multiple sclerosis: what have we learned? |
title_full_unstemmed | Gray matter imaging in multiple sclerosis: what have we learned? |
title_short | Gray matter imaging in multiple sclerosis: what have we learned? |
title_sort | gray matter imaging in multiple sclerosis: what have we learned? |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262750/ https://www.ncbi.nlm.nih.gov/pubmed/22152037 http://dx.doi.org/10.1186/1471-2377-11-153 |
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