Cargando…
CAG Repeat Variants in the POLG1 Gene Encoding mtDNA Polymerase-Gamma and Risk of Breast Cancer in African-American Women
The DNA polymerase-gamma (POLG) gene, which encodes the catalytic subunit of enzyme responsible for directing mitochondrial DNA replication in humans, contains a polyglutamine tract encoded by CAG repeats of varying length. The length of the CAG repeat has been associated with the risk of testicular...
Autores principales: | Azrak, Sami, Ayyasamy, Vanniarajan, Zirpoli, Gary, Ambrosone, Christine, Bandera, Elisa V., Bovbjerg, Dana H., Jandorf, Lina, Ciupak, Gregory, Davis, Warren, Pawlish, Karen S., Liang, Ping, Singh, Keshav |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262786/ https://www.ncbi.nlm.nih.gov/pubmed/22276120 http://dx.doi.org/10.1371/journal.pone.0029548 |
Ejemplares similares
-
p53 regulates mtDNA copy number and mitocheckpoint pathway
por: Kulawiec, Mariola, et al.
Publicado: (2009) -
Autophagy balances mtDNA synthesis and degradation by DNA polymerase POLG during starvation
por: Medeiros, Tânia Catarina, et al.
Publicado: (2018) -
Expression of catalytic mutants of the mtDNA helicase Twinkle and polymerase POLG causes distinct replication stalling phenotypes
por: Wanrooij, Sjoerd, et al.
Publicado: (2007) -
Innate Immunity Pathways and Breast Cancer Risk in African American and European-American Women in the Women’s Circle of Health Study (WCHS)
por: Gong, Zhihong, et al.
Publicado: (2013) -
Heterozygous Polg mutation causes motor dysfunction due to mtDNA deletions
por: Fuke, Satoshi, et al.
Publicado: (2014)