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Activation Mobilizes the Cholesterol in the Late Endosomes-Lysosomes of Niemann Pick Type C Cells

A variety of intercalating amphipaths increase the chemical activity of plasma membrane cholesterol. To test whether intracellular cholesterol can be similarly activated, we examined NPC1 and NPC2 fibroblasts, since they accumulate large amounts of cholesterol in their late endosomes and lysosomes (...

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Detalles Bibliográficos
Autores principales:	Lange, Yvonne, Ye, Jin, Steck, Theodore L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262792/ https://www.ncbi.nlm.nih.gov/pubmed/22276143 http://dx.doi.org/10.1371/journal.pone.0030051

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