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Atypical extragonadal germ cell tumors

AIM: To review the experience with the diagnosis and management of extragonadal germ cell tumors (GCT) with a subset analysis of those with atypical features. MATERIALS AND METHODS: A retrospective chart review of patients of extragonadal germ cell tumors between 2000 and 2010 was carried out. RESUL...

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Detalles Bibliográficos
Autores principales: Deb, Mainak, Mohanty, Suravi, Ananthamurthy, Anuradha, Garg, Isha, Das, Kanishka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3263044/
https://www.ncbi.nlm.nih.gov/pubmed/22279357
http://dx.doi.org/10.4103/0971-9261.91079
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author Deb, Mainak
Mohanty, Suravi
Ananthamurthy, Anuradha
Garg, Isha
Das, Kanishka
author_facet Deb, Mainak
Mohanty, Suravi
Ananthamurthy, Anuradha
Garg, Isha
Das, Kanishka
author_sort Deb, Mainak
collection PubMed
description AIM: To review the experience with the diagnosis and management of extragonadal germ cell tumors (GCT) with a subset analysis of those with atypical features. MATERIALS AND METHODS: A retrospective chart review of patients of extragonadal germ cell tumors between 2000 and 2010 was carried out. RESULTS: Fifteen children aged 7 days to 15 years (median, 1.5 years) were included. Three had an antenatal diagnosis (one sacrococcygeal, one retrobulbar, one retroperitoneal tumor) and were operated in the neonatal period. The locations were distributed between the retrobulbar area (1), anterior neck-thyroid gland (1), mediastinum (4), abdominothoracic extending through the esophageal hiatus (1), retroperitoneal (4) and sacrococcygeal (4). On histological examination, five harbored immature elements while two were malignant; the latter children received postexcision adjuvant chemotherapy. There was no mortality. At a median follow-up of 4.5 years (6 months to 8 years), 14/15 have had an event-free survival. One immature mediastinal teratoma that recurred locally 7.5 years after the initial operation was excised and adjuvant chemotherapy instituted. CONCLUSIONS: Extragonadal GCTs in children are uncommon and occasionally present with atypical clinical, radiological and histological features resulting in diagnostic and therapeutic dilemmas.
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spelling pubmed-32630442012-01-25 Atypical extragonadal germ cell tumors Deb, Mainak Mohanty, Suravi Ananthamurthy, Anuradha Garg, Isha Das, Kanishka J Indian Assoc Pediatr Surg Original Article AIM: To review the experience with the diagnosis and management of extragonadal germ cell tumors (GCT) with a subset analysis of those with atypical features. MATERIALS AND METHODS: A retrospective chart review of patients of extragonadal germ cell tumors between 2000 and 2010 was carried out. RESULTS: Fifteen children aged 7 days to 15 years (median, 1.5 years) were included. Three had an antenatal diagnosis (one sacrococcygeal, one retrobulbar, one retroperitoneal tumor) and were operated in the neonatal period. The locations were distributed between the retrobulbar area (1), anterior neck-thyroid gland (1), mediastinum (4), abdominothoracic extending through the esophageal hiatus (1), retroperitoneal (4) and sacrococcygeal (4). On histological examination, five harbored immature elements while two were malignant; the latter children received postexcision adjuvant chemotherapy. There was no mortality. At a median follow-up of 4.5 years (6 months to 8 years), 14/15 have had an event-free survival. One immature mediastinal teratoma that recurred locally 7.5 years after the initial operation was excised and adjuvant chemotherapy instituted. CONCLUSIONS: Extragonadal GCTs in children are uncommon and occasionally present with atypical clinical, radiological and histological features resulting in diagnostic and therapeutic dilemmas. Medknow Publications & Media Pvt Ltd 2012 /pmc/articles/PMC3263044/ /pubmed/22279357 http://dx.doi.org/10.4103/0971-9261.91079 Text en Copyright: © Journal of Indian Association of Pediatric Surgeons http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Deb, Mainak
Mohanty, Suravi
Ananthamurthy, Anuradha
Garg, Isha
Das, Kanishka
Atypical extragonadal germ cell tumors
title Atypical extragonadal germ cell tumors
title_full Atypical extragonadal germ cell tumors
title_fullStr Atypical extragonadal germ cell tumors
title_full_unstemmed Atypical extragonadal germ cell tumors
title_short Atypical extragonadal germ cell tumors
title_sort atypical extragonadal germ cell tumors
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3263044/
https://www.ncbi.nlm.nih.gov/pubmed/22279357
http://dx.doi.org/10.4103/0971-9261.91079
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