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Genetic association of TNF-α-308 G/A and -863 C/A polymorphisms with late onset Alzheimer's disease in Azeri Turk population of Iran

BACKGROUND: Recent findings suggest that production of pro-inflammatory cytokines, such as Tumour Necrosis Factor-alpha (TNF-α), is increased in the brain tissue of patients suffering late-onset Alzheimer's disease (LOAD) and play an important role in the pathogenesis of this disease. Several e...

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Autores principales: Ardebili, Seiied Moitaba Mohaddes, Yeghaneh, Tarlan, Gharesouran, Jalal, Rezazadeh, Maryam, Farhoudi, Mehdi, Ayromlou, Hormoz, Talebi, Mahnaz, Ghojazadeh, Morteza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications Pvt Ltd 2011
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3263076/
https://www.ncbi.nlm.nih.gov/pubmed/22279475
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author Ardebili, Seiied Moitaba Mohaddes
Yeghaneh, Tarlan
Gharesouran, Jalal
Rezazadeh, Maryam
Farhoudi, Mehdi
Ayromlou, Hormoz
Talebi, Mahnaz
Ghojazadeh, Morteza
author_facet Ardebili, Seiied Moitaba Mohaddes
Yeghaneh, Tarlan
Gharesouran, Jalal
Rezazadeh, Maryam
Farhoudi, Mehdi
Ayromlou, Hormoz
Talebi, Mahnaz
Ghojazadeh, Morteza
author_sort Ardebili, Seiied Moitaba Mohaddes
collection PubMed
description BACKGROUND: Recent findings suggest that production of pro-inflammatory cytokines, such as Tumour Necrosis Factor-alpha (TNF-α), is increased in the brain tissue of patients suffering late-onset Alzheimer's disease (LOAD) and play an important role in the pathogenesis of this disease. Several epidemiological studies also suggest that patients taking anti-inflammatory drugs have a decreased risk of developing AD. TNF-α is an important pro inflammatory cytokine that is unregulated in Alzheimer's patients. Functional polymorphisms in tumor necrosis factor alpha (TNF-α) can affect immune response, inflammation, tissue injury and possibly the susceptibility to Alzheimer disease (AD). METHODS: We used the polymorphic DNA markers (-308G/A) and (-863C/A) to study the association of TNF-α gene mutations with Late-onset Alzheimer's disease (LOAD) and the relation between clinical features and genotypes in affected individuals. A total of 160 patient samples and 163 healthy controls from west northern Iran (Eastern Azerbaijan) were genotyped for the two polymorphisms by the PCR-RFLP method and genotype frequencies were statistically determined. RESULTS: Our data showed significant difference in TNF-α-308 G/A genotype and pro inflammatory cytokine allele frequencies between the Alzheimer disease patients and healthy subjects. Contrary to that, no significant difference was observed in TNF-α-863 C/A genotype and allele frequencies between these two groups. CONCLUSIONS: TNF-α-308 G/A gene polymorphism could affect cerebral inflammatory response and the risk of late-onset Alzheimer disease but -863 C/A polymorphism does not influence the risk of this disease and this possible association between TNF-α -308G/A and -863C/A gene polymorphisms have to be further elucidated in larger case control studies.
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spelling pubmed-32630762012-01-25 Genetic association of TNF-α-308 G/A and -863 C/A polymorphisms with late onset Alzheimer's disease in Azeri Turk population of Iran Ardebili, Seiied Moitaba Mohaddes Yeghaneh, Tarlan Gharesouran, Jalal Rezazadeh, Maryam Farhoudi, Mehdi Ayromlou, Hormoz Talebi, Mahnaz Ghojazadeh, Morteza J Res Med Sci Original Article BACKGROUND: Recent findings suggest that production of pro-inflammatory cytokines, such as Tumour Necrosis Factor-alpha (TNF-α), is increased in the brain tissue of patients suffering late-onset Alzheimer's disease (LOAD) and play an important role in the pathogenesis of this disease. Several epidemiological studies also suggest that patients taking anti-inflammatory drugs have a decreased risk of developing AD. TNF-α is an important pro inflammatory cytokine that is unregulated in Alzheimer's patients. Functional polymorphisms in tumor necrosis factor alpha (TNF-α) can affect immune response, inflammation, tissue injury and possibly the susceptibility to Alzheimer disease (AD). METHODS: We used the polymorphic DNA markers (-308G/A) and (-863C/A) to study the association of TNF-α gene mutations with Late-onset Alzheimer's disease (LOAD) and the relation between clinical features and genotypes in affected individuals. A total of 160 patient samples and 163 healthy controls from west northern Iran (Eastern Azerbaijan) were genotyped for the two polymorphisms by the PCR-RFLP method and genotype frequencies were statistically determined. RESULTS: Our data showed significant difference in TNF-α-308 G/A genotype and pro inflammatory cytokine allele frequencies between the Alzheimer disease patients and healthy subjects. Contrary to that, no significant difference was observed in TNF-α-863 C/A genotype and allele frequencies between these two groups. CONCLUSIONS: TNF-α-308 G/A gene polymorphism could affect cerebral inflammatory response and the risk of late-onset Alzheimer disease but -863 C/A polymorphism does not influence the risk of this disease and this possible association between TNF-α -308G/A and -863C/A gene polymorphisms have to be further elucidated in larger case control studies. Medknow Publications Pvt Ltd 2011-08 /pmc/articles/PMC3263076/ /pubmed/22279475 Text en Copyright: © Journal of Research in Medical Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Ardebili, Seiied Moitaba Mohaddes
Yeghaneh, Tarlan
Gharesouran, Jalal
Rezazadeh, Maryam
Farhoudi, Mehdi
Ayromlou, Hormoz
Talebi, Mahnaz
Ghojazadeh, Morteza
Genetic association of TNF-α-308 G/A and -863 C/A polymorphisms with late onset Alzheimer's disease in Azeri Turk population of Iran
title Genetic association of TNF-α-308 G/A and -863 C/A polymorphisms with late onset Alzheimer's disease in Azeri Turk population of Iran
title_full Genetic association of TNF-α-308 G/A and -863 C/A polymorphisms with late onset Alzheimer's disease in Azeri Turk population of Iran
title_fullStr Genetic association of TNF-α-308 G/A and -863 C/A polymorphisms with late onset Alzheimer's disease in Azeri Turk population of Iran
title_full_unstemmed Genetic association of TNF-α-308 G/A and -863 C/A polymorphisms with late onset Alzheimer's disease in Azeri Turk population of Iran
title_short Genetic association of TNF-α-308 G/A and -863 C/A polymorphisms with late onset Alzheimer's disease in Azeri Turk population of Iran
title_sort genetic association of tnf-α-308 g/a and -863 c/a polymorphisms with late onset alzheimer's disease in azeri turk population of iran
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3263076/
https://www.ncbi.nlm.nih.gov/pubmed/22279475
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