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In vitro and in vivo evaluation of ordered mesoporous silica as a novel adsorbent in liquisolid formulation

BACKGROUND: A liquisolid technique has been reported to be a new approach to improve the release of poorly water-soluble drugs for oral administration. However, an apparent limitation of this technique is the formulation of a high dose because a large amount of liquid vehicle is needed, which finall...

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Autores principales: Chen, Bao, Wang, Zhouhua, Quan, Guilan, Peng, Xinsheng, Pan, Xin, Wang, Rongchang, Xu, Yuehong, Li, Ge, Wu, Chuanbin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3263412/
https://www.ncbi.nlm.nih.gov/pubmed/22275835
http://dx.doi.org/10.2147/IJN.S26763
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author Chen, Bao
Wang, Zhouhua
Quan, Guilan
Peng, Xinsheng
Pan, Xin
Wang, Rongchang
Xu, Yuehong
Li, Ge
Wu, Chuanbin
author_facet Chen, Bao
Wang, Zhouhua
Quan, Guilan
Peng, Xinsheng
Pan, Xin
Wang, Rongchang
Xu, Yuehong
Li, Ge
Wu, Chuanbin
author_sort Chen, Bao
collection PubMed
description BACKGROUND: A liquisolid technique has been reported to be a new approach to improve the release of poorly water-soluble drugs for oral administration. However, an apparent limitation of this technique is the formulation of a high dose because a large amount of liquid vehicle is needed, which finally results in a low-dose liquisolid formulation. Silica as an absorbent has been used extensively in liquisolid formulations. Although nanoparticle silica can be prepared and used to improve liquid adsorption capacity, loading a high dose of drug into a liquisolid is still a challenge. With the aim of improving adsorption capacity and accordingly achieving high drug loading, ordered mesoporous silica with a high surface area and narrow pore size distribution was synthesized and used in a liquisolid formulation. METHODS: Ordered mesoporous silica was synthesized and its particle size and morphology were tailored by controlling the concentration of cetyltrimethyl ammonium bromide. The ordered mesoporous silica synthesized was characterized by transmission electron microscopy, scanning electron microscopy, Fourier transform infrared spectroscopy, small-angle x-ray diffraction, wide angle x-ray diffraction, and nitrogen adsorption-desorption measurements. The liquid adsorption capacity of ordered mesoporous silica was subsequently compared with that of conventional silica materials using PEG400 as the model liquid. Carbamazepine was chosen as a model drug to prepare the liquisolid formulation, with ordered mesoporous silica as the adsorbent material. The preparation was evaluated and compared with commercially available fast-release carbamazepine tablets in vitro and in vivo. RESULTS: Characterization of the ordered mesoporous silica synthesized in this study indicated a huge Brunauer–Emmett–Teller surface area (1030 m(2)/g), an ordered mesoporous structure with a pore size of 2.8 nm, and high adsorption capacity for liquid compared with conventional silica. Compared with fast-release commercial carbamazepine tablets, drug release from the liquisolid capsules was greatly improved, and the bioavailability of the liquisolid preparation was enhanced by 182.7%. CONCLUSION: Ordered mesoporous silica is a potentially attractive adsorbent which may lead to a new approach for development of liquisolid products.
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spelling pubmed-32634122012-01-24 In vitro and in vivo evaluation of ordered mesoporous silica as a novel adsorbent in liquisolid formulation Chen, Bao Wang, Zhouhua Quan, Guilan Peng, Xinsheng Pan, Xin Wang, Rongchang Xu, Yuehong Li, Ge Wu, Chuanbin Int J Nanomedicine Original Research BACKGROUND: A liquisolid technique has been reported to be a new approach to improve the release of poorly water-soluble drugs for oral administration. However, an apparent limitation of this technique is the formulation of a high dose because a large amount of liquid vehicle is needed, which finally results in a low-dose liquisolid formulation. Silica as an absorbent has been used extensively in liquisolid formulations. Although nanoparticle silica can be prepared and used to improve liquid adsorption capacity, loading a high dose of drug into a liquisolid is still a challenge. With the aim of improving adsorption capacity and accordingly achieving high drug loading, ordered mesoporous silica with a high surface area and narrow pore size distribution was synthesized and used in a liquisolid formulation. METHODS: Ordered mesoporous silica was synthesized and its particle size and morphology were tailored by controlling the concentration of cetyltrimethyl ammonium bromide. The ordered mesoporous silica synthesized was characterized by transmission electron microscopy, scanning electron microscopy, Fourier transform infrared spectroscopy, small-angle x-ray diffraction, wide angle x-ray diffraction, and nitrogen adsorption-desorption measurements. The liquid adsorption capacity of ordered mesoporous silica was subsequently compared with that of conventional silica materials using PEG400 as the model liquid. Carbamazepine was chosen as a model drug to prepare the liquisolid formulation, with ordered mesoporous silica as the adsorbent material. The preparation was evaluated and compared with commercially available fast-release carbamazepine tablets in vitro and in vivo. RESULTS: Characterization of the ordered mesoporous silica synthesized in this study indicated a huge Brunauer–Emmett–Teller surface area (1030 m(2)/g), an ordered mesoporous structure with a pore size of 2.8 nm, and high adsorption capacity for liquid compared with conventional silica. Compared with fast-release commercial carbamazepine tablets, drug release from the liquisolid capsules was greatly improved, and the bioavailability of the liquisolid preparation was enhanced by 182.7%. CONCLUSION: Ordered mesoporous silica is a potentially attractive adsorbent which may lead to a new approach for development of liquisolid products. Dove Medical Press 2012 2012-01-06 /pmc/articles/PMC3263412/ /pubmed/22275835 http://dx.doi.org/10.2147/IJN.S26763 Text en © 2012 Chen et al, publisher and licensee Dove Medical Press Ltd. This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.
spellingShingle Original Research
Chen, Bao
Wang, Zhouhua
Quan, Guilan
Peng, Xinsheng
Pan, Xin
Wang, Rongchang
Xu, Yuehong
Li, Ge
Wu, Chuanbin
In vitro and in vivo evaluation of ordered mesoporous silica as a novel adsorbent in liquisolid formulation
title In vitro and in vivo evaluation of ordered mesoporous silica as a novel adsorbent in liquisolid formulation
title_full In vitro and in vivo evaluation of ordered mesoporous silica as a novel adsorbent in liquisolid formulation
title_fullStr In vitro and in vivo evaluation of ordered mesoporous silica as a novel adsorbent in liquisolid formulation
title_full_unstemmed In vitro and in vivo evaluation of ordered mesoporous silica as a novel adsorbent in liquisolid formulation
title_short In vitro and in vivo evaluation of ordered mesoporous silica as a novel adsorbent in liquisolid formulation
title_sort in vitro and in vivo evaluation of ordered mesoporous silica as a novel adsorbent in liquisolid formulation
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3263412/
https://www.ncbi.nlm.nih.gov/pubmed/22275835
http://dx.doi.org/10.2147/IJN.S26763
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