Safety and Efficacy of Thrombolytic Therapy Using rt-PA (Alteplase) in Acute Ischemic Stroke

The aim of this study was to evaluate the efficacy and safety of thrombolytic therapy. Our study enrolled 23 patients out of which 2 patients died due to ICH; we also found that only 39% of patients reached hospital within stroke window, and for those treated, mean NIHSS during admission was 14.0, b...

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Autores principales: Sivanandy, Palanisamy, Thomas, Binny, Krishnan, Vijayan, Arunachalam, Sumathy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scholarly Research Network 2011
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3263539/
https://www.ncbi.nlm.nih.gov/pubmed/22389825
http://dx.doi.org/10.5402/2011/618624
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author Sivanandy, Palanisamy
Thomas, Binny
Krishnan, Vijayan
Arunachalam, Sumathy
author_facet Sivanandy, Palanisamy
Thomas, Binny
Krishnan, Vijayan
Arunachalam, Sumathy
author_sort Sivanandy, Palanisamy
collection PubMed
description The aim of this study was to evaluate the efficacy and safety of thrombolytic therapy. Our study enrolled 23 patients out of which 2 patients died due to ICH; we also found that only 39% of patients reached hospital within stroke window, and for those treated, mean NIHSS during admission was 14.0, but drastic improvement was shown after 24 hours of treatment, that is, 9.89 (P < 0.0001), and at discharge, it was 5.1 (P < 0.0001) which showed a clear impact of the treatment, and around 60% of patients were discharged within an mRS score of 1 and 2. Hence, it was found that thrombolytic therapy was beneficial, efficacious, and safe if used within 3 to 4.5 hours.
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spelling pubmed-32635392012-03-02 Safety and Efficacy of Thrombolytic Therapy Using rt-PA (Alteplase) in Acute Ischemic Stroke Sivanandy, Palanisamy Thomas, Binny Krishnan, Vijayan Arunachalam, Sumathy ISRN Neurol Research Article The aim of this study was to evaluate the efficacy and safety of thrombolytic therapy. Our study enrolled 23 patients out of which 2 patients died due to ICH; we also found that only 39% of patients reached hospital within stroke window, and for those treated, mean NIHSS during admission was 14.0, but drastic improvement was shown after 24 hours of treatment, that is, 9.89 (P < 0.0001), and at discharge, it was 5.1 (P < 0.0001) which showed a clear impact of the treatment, and around 60% of patients were discharged within an mRS score of 1 and 2. Hence, it was found that thrombolytic therapy was beneficial, efficacious, and safe if used within 3 to 4.5 hours. International Scholarly Research Network 2011 2011-11-29 /pmc/articles/PMC3263539/ /pubmed/22389825 http://dx.doi.org/10.5402/2011/618624 Text en Copyright © 2011 Palanisamy Sivanandy et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Sivanandy, Palanisamy
Thomas, Binny
Krishnan, Vijayan
Arunachalam, Sumathy
Safety and Efficacy of Thrombolytic Therapy Using rt-PA (Alteplase) in Acute Ischemic Stroke
title Safety and Efficacy of Thrombolytic Therapy Using rt-PA (Alteplase) in Acute Ischemic Stroke
title_full Safety and Efficacy of Thrombolytic Therapy Using rt-PA (Alteplase) in Acute Ischemic Stroke
title_fullStr Safety and Efficacy of Thrombolytic Therapy Using rt-PA (Alteplase) in Acute Ischemic Stroke
title_full_unstemmed Safety and Efficacy of Thrombolytic Therapy Using rt-PA (Alteplase) in Acute Ischemic Stroke
title_short Safety and Efficacy of Thrombolytic Therapy Using rt-PA (Alteplase) in Acute Ischemic Stroke
title_sort safety and efficacy of thrombolytic therapy using rt-pa (alteplase) in acute ischemic stroke
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3263539/
https://www.ncbi.nlm.nih.gov/pubmed/22389825
http://dx.doi.org/10.5402/2011/618624
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