The Use of Dexamethasone in Bacterial Meningitis in Children and Adults: A Retrospective Analysis

Bacterial meningitis is a life-threatening illness that results from bacterial infection of the meninges and is associated with high mortality and morbidity rate, especially when the Streptococcus pneumoniae is the causative agent. Dexamethasone as adjunctive therapy to antibiotics does not influenc...

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Detalles Bibliográficos
Autores principales: Cornelis, An-Sophie, Hachimi-Idrissi, Said
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scholarly Research Network 2011
Materias:
Clinical Study
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3263580/
https://www.ncbi.nlm.nih.gov/pubmed/22389776
http://dx.doi.org/10.5402/2011/380283
Descripción
Sumario:Bacterial meningitis is a life-threatening illness that results from bacterial infection of the meninges and is associated with high mortality and morbidity rate, especially when the Streptococcus pneumoniae is the causative agent. Dexamethasone as adjunctive therapy to antibiotics does not influence the outcome or the complications in children as well as in adults suffering bacterial meningitis. However, we identified some prognostic parameters in the outcome of bacterial meningitis, and when dexamethasone was given in presence of at least one of 3 poor prognostic CSF parameters (WBC < 1000/mm(3), glucose < 20 mg/dl, lactate > 10 mg/dl) it substantially improved the outcome.

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