The Use of Dexamethasone in Bacterial Meningitis in Children and Adults: A Retrospective Analysis

Bacterial meningitis is a life-threatening illness that results from bacterial infection of the meninges and is associated with high mortality and morbidity rate, especially when the Streptococcus pneumoniae is the causative agent. Dexamethasone as adjunctive therapy to antibiotics does not influenc...

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Autores principales: Cornelis, An-Sophie, Hachimi-Idrissi, Said
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scholarly Research Network 2011
Materias:
Clinical Study
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3263580/
https://www.ncbi.nlm.nih.gov/pubmed/22389776
http://dx.doi.org/10.5402/2011/380283
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author Cornelis, An-Sophie
Hachimi-Idrissi, Said
author_facet Cornelis, An-Sophie
Hachimi-Idrissi, Said
author_sort Cornelis, An-Sophie
collection PubMed
description Bacterial meningitis is a life-threatening illness that results from bacterial infection of the meninges and is associated with high mortality and morbidity rate, especially when the Streptococcus pneumoniae is the causative agent. Dexamethasone as adjunctive therapy to antibiotics does not influence the outcome or the complications in children as well as in adults suffering bacterial meningitis. However, we identified some prognostic parameters in the outcome of bacterial meningitis, and when dexamethasone was given in presence of at least one of 3 poor prognostic CSF parameters (WBC < 1000/mm(3), glucose < 20 mg/dl, lactate > 10 mg/dl) it substantially improved the outcome.
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spelling pubmed-32635802012-03-02 The Use of Dexamethasone in Bacterial Meningitis in Children and Adults: A Retrospective Analysis Cornelis, An-Sophie Hachimi-Idrissi, Said ISRN Pediatr Clinical Study Bacterial meningitis is a life-threatening illness that results from bacterial infection of the meninges and is associated with high mortality and morbidity rate, especially when the Streptococcus pneumoniae is the causative agent. Dexamethasone as adjunctive therapy to antibiotics does not influence the outcome or the complications in children as well as in adults suffering bacterial meningitis. However, we identified some prognostic parameters in the outcome of bacterial meningitis, and when dexamethasone was given in presence of at least one of 3 poor prognostic CSF parameters (WBC < 1000/mm(3), glucose < 20 mg/dl, lactate > 10 mg/dl) it substantially improved the outcome. International Scholarly Research Network 2011 2011-12-28 /pmc/articles/PMC3263580/ /pubmed/22389776 http://dx.doi.org/10.5402/2011/380283 Text en Copyright © 2011 A.-S. Cornelis and S. Hachimi-Idrissi. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Cornelis, An-Sophie
Hachimi-Idrissi, Said
The Use of Dexamethasone in Bacterial Meningitis in Children and Adults: A Retrospective Analysis
title The Use of Dexamethasone in Bacterial Meningitis in Children and Adults: A Retrospective Analysis
title_full The Use of Dexamethasone in Bacterial Meningitis in Children and Adults: A Retrospective Analysis
title_fullStr The Use of Dexamethasone in Bacterial Meningitis in Children and Adults: A Retrospective Analysis
title_full_unstemmed The Use of Dexamethasone in Bacterial Meningitis in Children and Adults: A Retrospective Analysis
title_short The Use of Dexamethasone in Bacterial Meningitis in Children and Adults: A Retrospective Analysis
title_sort use of dexamethasone in bacterial meningitis in children and adults: a retrospective analysis
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3263580/
https://www.ncbi.nlm.nih.gov/pubmed/22389776
http://dx.doi.org/10.5402/2011/380283
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