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Effect of an Oral Adsorbent, AST-120, on Dialysis Initiation and Survival in Patients with Chronic Kidney Disease

The oral adsorbent AST-120 has the potential to delay dialysis initiation and improve survival of patients on dialysis. We evaluated the effect of AST-120 on dialysis initiation and its potential to improve survival in patients with chronic kidney disease. The present retrospective pair-matched stud...

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Autores principales: Hatakeyama, Shingo, Yamamoto, Hayato, Okamoto, Akiko, Imanishi, Kengo, Tokui, Noriko, Okamoto, Teppei, Suzuki, Yuichiro, Sugiyama, Naoaki, Imai, Atsushi, Kudo, Shigemasa, Yoneyama, Takahiro, Hashimoto, Yasuhiro, Koie, Takuya, Kaminura, Noritaka, Saitoh, Hisao, Funyu, Tomihisa, Ohyama, Chikara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3263620/
https://www.ncbi.nlm.nih.gov/pubmed/22288014
http://dx.doi.org/10.1155/2012/376128
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author Hatakeyama, Shingo
Yamamoto, Hayato
Okamoto, Akiko
Imanishi, Kengo
Tokui, Noriko
Okamoto, Teppei
Suzuki, Yuichiro
Sugiyama, Naoaki
Imai, Atsushi
Kudo, Shigemasa
Yoneyama, Takahiro
Hashimoto, Yasuhiro
Koie, Takuya
Kaminura, Noritaka
Saitoh, Hisao
Funyu, Tomihisa
Ohyama, Chikara
author_facet Hatakeyama, Shingo
Yamamoto, Hayato
Okamoto, Akiko
Imanishi, Kengo
Tokui, Noriko
Okamoto, Teppei
Suzuki, Yuichiro
Sugiyama, Naoaki
Imai, Atsushi
Kudo, Shigemasa
Yoneyama, Takahiro
Hashimoto, Yasuhiro
Koie, Takuya
Kaminura, Noritaka
Saitoh, Hisao
Funyu, Tomihisa
Ohyama, Chikara
author_sort Hatakeyama, Shingo
collection PubMed
description The oral adsorbent AST-120 has the potential to delay dialysis initiation and improve survival of patients on dialysis. We evaluated the effect of AST-120 on dialysis initiation and its potential to improve survival in patients with chronic kidney disease. The present retrospective pair-matched study included 560 patients, grouped according to whether or not they received AST-120 before dialysis (AST-120 and non-AST-120 groups). The cumulative dialysis initiation free rate and survival rate were compared by the Kaplan-Meier method. Multivariate analysis was used to determine the impact of AST-120 on dialysis initiation. Our results showed significant differences in the 12- and 24-month dialysis initiation free rate (P < 0.001), although no significant difference was observed in the survival rate between the two groups. In conclusion, AST-120 delays dialysis initiation in chronic kidney disease (CKD) patients but has no effect on survival. AST-120 is an effective therapy for delaying the progression of CKD.
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spelling pubmed-32636202012-01-27 Effect of an Oral Adsorbent, AST-120, on Dialysis Initiation and Survival in Patients with Chronic Kidney Disease Hatakeyama, Shingo Yamamoto, Hayato Okamoto, Akiko Imanishi, Kengo Tokui, Noriko Okamoto, Teppei Suzuki, Yuichiro Sugiyama, Naoaki Imai, Atsushi Kudo, Shigemasa Yoneyama, Takahiro Hashimoto, Yasuhiro Koie, Takuya Kaminura, Noritaka Saitoh, Hisao Funyu, Tomihisa Ohyama, Chikara Int J Nephrol Clinical Study The oral adsorbent AST-120 has the potential to delay dialysis initiation and improve survival of patients on dialysis. We evaluated the effect of AST-120 on dialysis initiation and its potential to improve survival in patients with chronic kidney disease. The present retrospective pair-matched study included 560 patients, grouped according to whether or not they received AST-120 before dialysis (AST-120 and non-AST-120 groups). The cumulative dialysis initiation free rate and survival rate were compared by the Kaplan-Meier method. Multivariate analysis was used to determine the impact of AST-120 on dialysis initiation. Our results showed significant differences in the 12- and 24-month dialysis initiation free rate (P < 0.001), although no significant difference was observed in the survival rate between the two groups. In conclusion, AST-120 delays dialysis initiation in chronic kidney disease (CKD) patients but has no effect on survival. AST-120 is an effective therapy for delaying the progression of CKD. Hindawi Publishing Corporation 2012-01-12 /pmc/articles/PMC3263620/ /pubmed/22288014 http://dx.doi.org/10.1155/2012/376128 Text en Copyright © 2012 Shingo Hatakeyama et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Hatakeyama, Shingo
Yamamoto, Hayato
Okamoto, Akiko
Imanishi, Kengo
Tokui, Noriko
Okamoto, Teppei
Suzuki, Yuichiro
Sugiyama, Naoaki
Imai, Atsushi
Kudo, Shigemasa
Yoneyama, Takahiro
Hashimoto, Yasuhiro
Koie, Takuya
Kaminura, Noritaka
Saitoh, Hisao
Funyu, Tomihisa
Ohyama, Chikara
Effect of an Oral Adsorbent, AST-120, on Dialysis Initiation and Survival in Patients with Chronic Kidney Disease
title Effect of an Oral Adsorbent, AST-120, on Dialysis Initiation and Survival in Patients with Chronic Kidney Disease
title_full Effect of an Oral Adsorbent, AST-120, on Dialysis Initiation and Survival in Patients with Chronic Kidney Disease
title_fullStr Effect of an Oral Adsorbent, AST-120, on Dialysis Initiation and Survival in Patients with Chronic Kidney Disease
title_full_unstemmed Effect of an Oral Adsorbent, AST-120, on Dialysis Initiation and Survival in Patients with Chronic Kidney Disease
title_short Effect of an Oral Adsorbent, AST-120, on Dialysis Initiation and Survival in Patients with Chronic Kidney Disease
title_sort effect of an oral adsorbent, ast-120, on dialysis initiation and survival in patients with chronic kidney disease
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3263620/
https://www.ncbi.nlm.nih.gov/pubmed/22288014
http://dx.doi.org/10.1155/2012/376128
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